Genetic Epidemiology of Pathological Gambling

病态赌博的遗传流行病学

• 批准号: 6704721
• 负责人: WENDY S SLUTSKE
• 金额: $ 49.23万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6704721
• 关键词: alcoholism /alcohol abuse; antisocial personality; behavioral /social science research tag; clinical research; comorbidity; disease /disorder etiology; family genetics; gamblings; gene environment interaction; genetic susceptibility; human subject; interview; personality disorders; statistics /biometry; twin /multiplet

DESCRIPTION (provided by applicant): Pathological gambling (PG) has become a major public health concern due to an unprecedented rate of growth of legalized gambling venues such as casinos and state lotteries over the past two decades; the prevalence of PG in the United States is predicted to increase with the increased access to gambling opportunities. However, the currently low lifetime prevalence of PG disorder of about 1-2% in the United States, coupled with low rates of treatment seeking among those affected, poses a considerable challenge for current epidemiologic research. This application successfully deals with this problem, by identifying a setting, Australia, where the prevalence of PG is now higher than it currently is in the United States. Australia is the ideal setting in which to conduct a community-based study of PG, and is also well suited for a genetic epidemiologic investigation because it will allow for an examination of the genetic influence on PG susceptibility in a culture in which most individuals have been heavily exposed to gambling opportunities. The broad aim of this proposal is to examine, using epidemiologic and biometrical modeling approaches, the causes of PG and problem gambling among both women and men. Telephone interview assessments of PG and problem gambling and questionnaire assessments of personality and antisocial behavior disorders will be conducted with a target sample of 10,518 individuals (5,885 women, 4,633 men) from 5,259 twin pairs (2,235 monozygotic pairs, 1,697 same-sex dizygotic pairs, and 1,327 unlike-sex dizygotic pairs) from the national Australian Twin Registry. These data will be analyzed in conjunction with structured psychiatric interview assessments of lifetime history of alcohol dependence, major depression, and conduct disorder collected in 1992-1994 or 1996-2000 and questionnaire assessments of major dimensions of personality collected in 1988 or 1989 in order to examine: (a) the relative contributions of genetic and environmental factors to the risk for PG and problem gambling, (b) the lifetime co-occurrence of PG and problem gambling with alcohol dependence and comorbid psychiatric disorders and the causes of co-occurrence, and (c) the role of personality in the etiology and comorbidity of PG and problem gambling.

描述（由申请人提供）：由于赌场和国家彩票等合法赌博场所在过去二十年中以前所未有的速度增长，病态赌博（PG）已成为主要的公共卫生问题；随着赌博机会的增加，预计 PG 在美国的流行率将会增加。然而，目前美国 PG 疾病的终生患病率较低，约为 1-2%，加上受影响人群寻求治疗的比例较低，对当前的流行病学研究提出了相当大的挑战。该应用程序通过确定一个环境（澳大利亚）成功地解决了这个问题，该地区 PG 的患病率目前高于美国。澳大利亚是进行基于社区的 PG 研究的理想环境，也非常适合进行遗传流行病学调查，因为它可以在大多数人都经历过的文化中检查遗传对 PG 易感性的影响。严重接触赌博机会。该提案的主要目标是利用流行病学和生物识别建模方法，研究女性和男性中 PG 和问题赌博的原因。 PG 和问题赌博的电话访谈评估以及人格和反社会行为障碍的问卷评估将以 5,259 对双胞胎（2,235 对同性异卵对、1,697 对同性异卵对、以及来自澳大利亚国家双胞胎登记处的 1,327 对不同性别的异卵对）。这些数据将与 1992-1994 年或 1996-2000 年收集的酒精依赖、重度抑郁和行为障碍终生史的结构化精神病学访谈评估以及 1988 年或 1989 年收集的人格主要维度的问卷评估结合起来进行分析，以便检查：(a) 遗传和环境因素对 PG 和问题赌博风险的相对贡献，(b) PG 和问题赌博的一生同时发生酒精依赖和共病精神疾病以及同时发生的原因，以及（c）人格在 PG 和问题赌博的病因和共病中的作用。