Context-specific spatial adaptation of the VOR

VOR 的特定环境空间适应

• 批准号: 6468215
• 负责人: SERGEI YAKUSHIN
• 金额: $ 35.09万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6468215
• 关键词: Macaca fascicularis; balance; behavior test; behavioral /social science research tag; brain electrical activity; electrical measurement; environmental adaptation; gravity; microelectrodes; neural information processing; neural plasticity; neuropsychology; proprioception /kinesthesia; psychometrics; sensorimotor system; sensory receptors; space perception; vestibular apparatus; vestibular nerve; vestibular pathway; vestibuloocular reflex; visual perception

DESCRIPTION:(provided by applicant) The purpose of this research is to characterize how adaptation of the angular vestibulo-ocular (aVOR) reflex depends on head orientation with regard to gravity and to determine its neural basis. The horizontal, vertical and torsional component of the aVOR will be adaptively increased and decreased in cynomolgus monkey (Macaca fascicularis) with the head in different positions. Angular rotation that is in-phase or out-of-phase with the visual surround will be used to decrease or increase the gain of the aVOR, respectively. Data obtained before and after adaptation will be compared. Magnitude of adaptive changes in various head orientations will be studied after one of the aVOR components has been adapted in a particular head position. Functional dependence of context-specific gain changes will be determined for each aVOR component. We expect that the amount of gain change will be maximal with the head in the same position in which the aVOR was adapted, and that changes will decrease as the head is deviated from this position. Based on the results of this experiment, our previous aVOR model will be extended to account for context specific gain changes. The neuronal basis of the context specific adaptation will be studied. When these studies are completed, we will have characterized context specific adaptation for canal activation in any plane and will have provided insights into the neural basis for this adaptation. An understanding of the neural basis of the context specific adaptation with regard to gravity is of considerable scientific interest, because this type of knowledge could have important implications for understanding adjustments to visual-vestibular conflict in gravitational environments. We postulate that context specific adaptation is one of the basic properties of the aVOR that is critical for orientation in three-dimensional space in the presence of gravity. Therefore, understanding of this phenomenon will significantly advance our knowledge of how the canals and otolith interact to maintain gaze stability.

描述：（申请人提供） 这项研究的目的是表征角度的适应 前庭 - 眼反射取决于头部方向 重力并确定其神经基础。水平，垂直和 AVOR的扭转成分将自适应地增加并减少 cynomolgus猴子（Macaca fascicularis）头部处于不同的位置。 角度旋转是与视觉周围的相相或相外的旋转 分别用于减少或增加avor的增益。数据 将比较在适应前后获得的。适应性的大小 在一个Avor之后，将研究各种头部方向的变化 组件已在特定的头部位置进行了调整。功能 每个avor都将确定上下文特定增益的依赖性 成分。我们希望随着收益变化的数量将是最大的 前往适应Avor的相同位置，该更改将会 当头部偏离该位置时，减小。基于 这个实验，我们以前的Avor模型将是 扩展以说明上下文特定的增益更改。神经元基础 将研究上下文特定的适应。当这些研究是 完成后，我们将表征对运河的特定环境适应 在任何平面中激活，都将提供对神经基础的见解 为此适应。对上下文神经基础的理解 关于重力的具体适应性是相当科学的 兴趣，因为这种知识可能对 了解重力中对视觉范围冲突的调整 环境。我们假设特定环境是基本的适应性 Avor的特性对于三维方向至关重要 在引力存在的空间。因此，了解这种现象 将大大提高我们对运河和耳石如何相互作用的了解 保持目光的稳定性。