Context-specific spatial adaptation of the VOR

VOR 的特定环境空间适应

• 批准号: 6468215
• 负责人: SERGEI YAKUSHIN
• 金额: $ 35.09万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6468215
• 关键词: Macaca fascicularis; balance; behavior test; behavioral /social science research tag; brain electrical activity; electrical measurement; environmental adaptation; gravity; microelectrodes; neural information processing; neural plasticity; neuropsychology; proprioception /kinesthesia; psychometrics; sensorimotor system; sensory receptors; space perception; vestibular apparatus; vestibular nerve; vestibular pathway; vestibuloocular reflex; visual perception

DESCRIPTION:(provided by applicant) The purpose of this research is to characterize how adaptation of the angular vestibulo-ocular (aVOR) reflex depends on head orientation with regard to gravity and to determine its neural basis. The horizontal, vertical and torsional component of the aVOR will be adaptively increased and decreased in cynomolgus monkey (Macaca fascicularis) with the head in different positions. Angular rotation that is in-phase or out-of-phase with the visual surround will be used to decrease or increase the gain of the aVOR, respectively. Data obtained before and after adaptation will be compared. Magnitude of adaptive changes in various head orientations will be studied after one of the aVOR components has been adapted in a particular head position. Functional dependence of context-specific gain changes will be determined for each aVOR component. We expect that the amount of gain change will be maximal with the head in the same position in which the aVOR was adapted, and that changes will decrease as the head is deviated from this position. Based on the results of this experiment, our previous aVOR model will be extended to account for context specific gain changes. The neuronal basis of the context specific adaptation will be studied. When these studies are completed, we will have characterized context specific adaptation for canal activation in any plane and will have provided insights into the neural basis for this adaptation. An understanding of the neural basis of the context specific adaptation with regard to gravity is of considerable scientific interest, because this type of knowledge could have important implications for understanding adjustments to visual-vestibular conflict in gravitational environments. We postulate that context specific adaptation is one of the basic properties of the aVOR that is critical for orientation in three-dimensional space in the presence of gravity. Therefore, understanding of this phenomenon will significantly advance our knowledge of how the canals and otolith interact to maintain gaze stability.

描述：（由申请人提供） 本研究的目的是描述角度的适应如何 前庭眼 (aVOR) 反射取决于头部方向 重力并确定其神经基础。水平、垂直和 aVOR 的扭转分量将自适应地增加和减少 食蟹猴（食蟹猴）的头部处于不同的位置。 与视觉环绕同相或异相的角度旋转将 分别用于减少或增加 aVOR 的增益。数据 将比较适应之前和之后获得的结果。自适应的幅度 在其中一项 aVOR 之后，将研究各种头部方向的变化 组件已针对特定的头部位置进行了调整。功能性 将为每个 aVOR 确定上下文特定增益变化的依赖性 成分。我们预计增益变化量将最大 头部处于调整 aVOR 的相同位置，并且该变化将 当头部偏离该位置时减小。根据结果 这个实验，我们之前的 aVOR 模型将是 扩展以考虑上下文特定的增益变化。神经元基础 将研究具体情况的适应。当这些研究 完成后，我们将针对运河的具体情况进行适应性调整 在任何平面上激活，并将提供对神经基础的见解 对于这个适应。了解上下文的神经基础 对重力的具体适应具有相当大的科学意义 兴趣，因为这类知识可能对以下方面产生重要影响： 了解重力中视觉前庭冲突的调整 环境。我们假设上下文特定的适应是基本的之一 aVOR 的特性对于三维定向至关重要 存在重力的空间。因此，对这一现象的认识 将极大地增进我们对耳管和耳石如何相互作用的了解 以保持视线稳定。