Clinical Trials in Graft versus Host Disease

移植物抗宿主病的临床试验

• 批准号: 6663092
• 负责人: GEORGIA B VOGELSANG
• 金额: $ 14.46万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6663092
• 关键词: artificial immunosuppression; bone marrow transplantation; clinical trial phase I; cyclophosphamide; flow cytometry; graft versus host disease; homologous transplantation; human subject; human therapy evaluation; leukemia; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; patient oriented research; artificial immunosuppression; bone marrow transplantation; clinical trial phase I; cyclophosphamide; flow cytometry; graft versus host disease; homologous transplantation; human subject; human therapy evaluation; leukemia; neoplasm /cancer immunology; neoplasm /cancer immunotherapy; patient oriented research

I am committed to clinical research to advance the treatment of patients with hematologic malignancies. To accomplish this goal, a new generation of clinical investigators must be trained. My major obstacle to pursuing clinical research and training is time pressures from clinical and administrative obligations. This award would guarantee protected time for clinical research and mentoring. The studies proposed are reflective of my strong interest in Graft versus Host disease. Each study was developed with the fellow or junior faculty member. The studies reflect the spectrum of graft versus those disease including the use of non myeloablative preparative regimens for high risk donor transplants, treatment of steroid refractory Graft versus Host disease in a study examining the pharmacokinetics of Pentostatin, and a staging system for chronic graft versus host disease. Besides meeting weekly with the trainees, formal course work will be taken through the School of Hygiene and Public Health Masters in the Clinical Investigation program. I also plan to take some of the courses to complement my recently completed MBA. Formal evaluation of my effectiveness will be obtained to improve my mentoring skills and to monitor my clinical research productivity.

我致力于临床研究，以促进血液学恶性肿瘤患者的治疗。为了实现这一目标，必须培训新一代的临床研究人员。我进行临床研究和培训的主要障碍是临床和行政义务的时间压力。该奖项将保证受保护的临床研究和指导时间。提出的研究反映了我对移植物与宿主疾病的强烈兴趣。每项研究都是由研究员或初级教师进行的。该研究反映了移植物与疾病的谱系，包括使用非骨髓性制备方案进行高风险供体移植，在研究五骨蛋白毒素的药代动力学的研究中，治疗类固醇难治性移植物与宿主疾病的治疗，以及用于慢性移植物与宿主疾病的分阶段的药代动力学。除了每周与学员开会外，还将通过临床调查计划中的卫生和公共卫生硕士学位进行正式课程工作。我还计划参加一些课程，以补充我最近完成的MBA。将对我的有效性进行正式评估，以提高我的指导能力并监测我的临床研究生产力。