Neuroanatomy of the Auditory System

听觉系统的神经解剖学

• 批准号: 6783092
• 负责人: Nell B. Cant
• 金额: $ 5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783092
• 关键词: auditory cortex; auditory nuclei; auditory pathways; axon; brain mapping; cell type; gerbil /jird; histochemistry /cytochemistry; immunocytochemistry; inferior colliculus; innervation; neuroanatomy; neuronal transport; olivary body; auditory cortex; auditory nuclei; auditory pathways; axon; brain mapping; cell type; gerbil /jird; histochemistry /cytochemistry; immunocytochemistry; inferior colliculus; innervation; neuroanatomy; neuronal transport; olivary body

The long-term objective is to understand the organization of the brainstem auditory pathways in terms of connections among the multiple neuronal types that form them. The objective of the proposed studies is an analysis of the termination patterns of specific cell types projecting into and out of the inferior colliculus (IC) of the gerbil. Nine experiments are proposed to achieve three specific aims: 1) To further characterize a) the multipolar cell pathway(s) from the ventral cochlear nucleus to the IC and b) the fusiform and giant cell pathways from the dorsal cochlear nucleus to the IC; 2) To determine the extent to which the descending projections from the auditory cortex to the IC overlap with ascending projections from the superior olivary complex versus those from the cochlear nuclei; 3) To determine whether different collicular domains give rise to projections to different parts of the medial geniculate nucleus. The working hypothesis that unites the specific aims is that zones in the inferior colliculus can be identified which are the targets of specific subsets of the ascending pathways and, further, that these zones project differentially into the forebrain. Neuroanatomical methods to be employed include techniques based on the anterograde and/or retrograde axonal transport of various tracer molecules; immunocytochemistry, and histochemistry. Neuroanatomical studies such as the ones proposed provide information essential for reaching an understanding of the mechanisms of auditory processing. The neuronal activity that leads to functional expression is dependent on the precise and specific connections among the hundreds of specialized neuronal types which collectively form the auditory system. Detailed understanding of these connections will not only help to explain available functional data, they will also provide a basis for developing rational hypotheses about auditory function that can be tested further.

长期目标是了解形成它们的多种神经元类型之间的联系。拟议的研究的目的是分析出进入沙鼠的下丘（IC）的特定细胞类型的终止模式。 提出了九个实验以实现三个特定目的：1）进一步表征a）多极细胞途径（s）从腹侧耳蜗核到IC和b）从背部耳蜗核到IC的梭形和巨型细胞途径； 2）确定从听觉皮层到IC重叠的程度，与上橄榄络合物的上升投影相比，与耳蜗核的升高有关； 3）确定不同的胶原结构域是否会引起内侧基因核不同部分的投影。 统一特定目的的工作假设是，可以识别下丘的区域，这是升上途径的特定子集的目标，进一步，这些区域将这些区域的投射差异化为前脑。 要使用的神经解剖学方法包括基于各种示踪剂分子的顺行和/或逆行轴突转运的技术；免疫细胞化学和组织化学。诸如提议的神经解剖学研究为了解听觉处理机制的理解提供了必不可少的信息。 导致功能表达的神经元活性取决于数百种专业的神经元类型之间的精确和特定连接，这些连接共同形成了听觉系统。 对这些连接的详细了解不仅有助于解释可用的功能数据，还将为开发有关听觉功能的理性假设提供基础，可以进一步测试。