HIGH FIELD MR RESEARCH IN DRUG ABUSE

药物滥用领域的高领域 MR 研究

• 批准号: 6612683
• 负责人: PERRY FRANKLIN RENSHAW
• 金额: $ 69.08万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-05 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6612683
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; blood flow measurement; body movement; brain circulation; brain electrical activity; brain imaging /visualization /scanning; brain mapping; computer system design /evaluation; drug abuse; drug addiction; electroencephalography; functional magnetic resonance imaging; human subject; image enhancement; infrared spectrometry; magnetic resonance imaging; mathematical model; neurochemistry; patient oriented research; phantom model; pharmacokinetics; statistics /biometry; substance abuse related behavior

DESCRIPTION (Provided by the Applicant): Magnetic resonance spectroscopy (MRS) and functional magnetic resonance imaging (fMRI) are extraordinarily promising new imaging modalities that are increasing our understanding of the nature of drug abuse and addiction. In March, 1999, the Office of National Drug Control Policy (ONDCP) and McLean Hospital agreed to jointly fund a Varian NMR Systems 4.0 T MR scanner which will be dedicated to substance abuse research at the McLean Brain Imaging Center. The present BRP application describes a series of ten engineering projects which will enhance the capabilities of this unique magnetic resonance research center to conduct studies of individuals with substance abuse disorders. This research program will involve bioengineering and clinical investigators at McLean Hospital, the Beth Israel Hospital, Tufts University, Boston University, the University of Washington, the University of Oxford, the University of California, San Francisco, and Wayne State University. Specific projects are summarized below: 1. Objective motion detection and correction in time series fMRI experiments. 2. Optimized phased array coil design. 3. FMRI image registration and signal dropout reduction in brain regions with high susceptibility effects. 4. Functional T2 relaxometry of brainstem and midbrain monoaminergic nuclei. 5. Estimation of cerebral blood flow and volume using dynamic susceptibility contrast MRI. 6. Proton echo-planar spectroscopic imaging at 4 T. 7. Two-dimensional, proton magnetic resonance spectroscopy of amino acid neurotransmitters. 8. Statistical methods for assessing drug effects and confounds in MRS and fMRI studies. 9. Concurrent, high resolution optical imaging and fMRI. 10. Concurrent EEG and fMRI assessment of drug-induced alpha wave activity. All of the projects listed above have been have been designed to address technical limitations encountered in the course of conducting NIDA-funded clinical imaging studies at 1.5 T field strength. Importantly, funds requested for this BRP will be used exclusively to support the engineering aspects of the research projects.

描述（由申请人提供）：磁共振波谱（MRS） 和功能磁共振成像（fMRI）非常有前途 新的成像方式正在增加我们对事物本质的理解 药物滥用和成瘾。 1999年3月，国家药品监督管理局 Policy (ONDCP) 和 McLean 医院同意共同资助瓦里安 NMR 系统 4.0 T MR 扫描仪将致力于药物滥用研究 麦克莱恩脑成像中心。目前的 BRP 应用描述了一系列 十个工程项目将增强这个独特的能力 磁共振研究中心对患有此病的个体进行研究 药物滥用障碍。该研究计划将涉及生物工程 塔夫茨麦克莱恩医院、贝斯以色列医院的临床研究人员 大学、波士顿大学、华盛顿大学、华盛顿大学 牛津大学、加州大学旧金山分校和韦恩州立大学 大学。具体项目概述如下： 一、目标动议 时间序列功能磁共振成像实验中的检测和校正。 2. 分阶段优化 阵列线圈设计。 3. FMRI 图像配准和信号丢失减少 具有高易感性效应的大脑区域。 4. 功能性 T2 松弛测量 脑干和中脑单胺能核。 5. 脑血的估计 使用动态磁敏感对比 MRI 测量流量和容量。 6. 质子 4 T 的平面回波光谱成像。 7. 二维质子磁性 氨基酸神经递质的共振光谱。八、统计方法 用于评估 MRS 和 fMRI 研究中的药物效应和混杂因素。 9. 并行、高分辨率光学成像和功能磁共振成像。 10. 同步脑电图和 药物诱导的 α 波活动的功能磁共振成像评估。列出的所有项目 以上旨在解决遇到的技术限制 在 NIDA 资助的 1.5 T 场临床成像研究过程中 力量。重要的是，为此 BRP 申请的资金将专门用于 支持研究项目的工程方面。