Word Encoding and Recognition in Schizophrenia

精神分裂症的单词编码和识别

• 批准号: 6621559
• 负责人: John D Ragland
• 金额: $ 19.81万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621559
• 关键词: behavioral /social science research tag; functional magnetic resonance imaging; gender difference; human subject; learning disorders; memory; neural information processing; neuropsychological tests; neuropsychology; patient oriented research; prefrontal lobe /cortex; psychometrics; schizophrenia; semantics; speech recognition; temporal lobe /cortex; verbal learning

DESCRIPTION (provided by applicant): The goal of the proposed research is to use functional magnetic resonance imaging (fMRI) to test two primary hypotheses about the nature of memory impairments in schizophrenia. The first is that impaired episodic memory in schizophrenia is related to dysfunctional semantic processing, reflected in failure to activate left inferior frontal gyrus (LIFG) during word encoding and recognition. The second hypothesis is that this LIFG dysfunction is primarily due to patients' impaired controlled processing of semantic information, rather than degradation of their semantic memory knowledge or automatic associative processes. The first hypothesis will be tested in experiments 1 & 2. Experiment one will employ the Penn Word Recognition Test (PWRT) which will allow us to replicate previous Positron Emission Tomography findings that impaired episodic memory is related to LIFG dysfunction during word encoding and retrieval. Experiment 2 will employ a shallow/deep word encoding and recognition paradigm that will permit us to test the role of self-generated organizational strategies in the semantic processing difficulties and related LIFG dysfunction in schizophrenia. The second primary hypothesis will be tested in the final two experiments. Experiment 3 will employ a cued semantic verbal fluency paradigm that will allow us to investigate the effect of reducing controlled processing demands on verbal fluency and LIFG function. The final experiment will use an uncued verbal fluency design that will permit a trial-by-trial examination of the effect of controlled versus automatic processing on LIFG function. This series of studies promises to uncover fundamental mechanisms of impaired semantic processing and related episodic memory and LIFG deficits in schizophrenia. Establishing this mechanism will lay the groundwork for future imaging studies and can help provide a rationale for developing cognitive interventions designed to remediate semantic processing and verbal memory deficits in schizophrenia in order to improve functional outcome.

描述（由申请人提供）：拟议研究的目的是 使用功能磁共振成像（fMRI）测试两个主要假设 关于精神分裂症中记忆障碍的性质。首先是 精神分裂症中的情节记忆受损与功能失调的语义有关 处理，反映在未能激活左下额回（LIFG）的情况下 在单词编码和识别过程中。第二个假设是这个Lifg 功能障碍主要是由于患者的受控处理受损 语义信息，而不是降解其语义记忆 知识或自动关联过程。 第一个假设将在实验1和2中进行检验。实验将会 采用Penn单词识别测试（PWRT），该测试将使我们复制 以前的正电子发射断层扫描发现障碍情节记忆是 与单词编码和检索过程中的LIFG功能障碍有关。实验2 将采用一个浅/深的单词编码和识别范式将 允许我们测试自我生成的组织策略在 精神分裂症的语义处理困难和相关的LIFG功能障碍。 第二个主要假设将在最后两个实验中进行测试。 实验3将采用提示的语义语言流利性范式 允许我们调查减少受控处理需求对 口头流利性和LIFG功能。最后的实验将使用未经的 言语流利性设计将允许对 受控与自动处理对LIFG功能的影响。 这一系列研究有望发现受损的基本机制 语义处理以及相关的情节记忆和LIFG缺陷 精神分裂症。建立这种机制将为未来奠定基础 成像研究，可以帮助发展认知的理由 旨在补救语义处理和口头记忆的干预措施 精神分裂症的缺陷以改善功能结果。