Word Encoding and Recognition in Schizophrenia

精神分裂症的单词编码和识别

• 批准号: 6621559
• 负责人: John D Ragland
• 金额: $ 19.81万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621559
• 关键词: behavioral /social science research tag; functional magnetic resonance imaging; gender difference; human subject; learning disorders; memory; neural information processing; neuropsychological tests; neuropsychology; patient oriented research; prefrontal lobe /cortex; psychometrics; schizophrenia; semantics; speech recognition; temporal lobe /cortex; verbal learning

DESCRIPTION (provided by applicant): The goal of the proposed research is to use functional magnetic resonance imaging (fMRI) to test two primary hypotheses about the nature of memory impairments in schizophrenia. The first is that impaired episodic memory in schizophrenia is related to dysfunctional semantic processing, reflected in failure to activate left inferior frontal gyrus (LIFG) during word encoding and recognition. The second hypothesis is that this LIFG dysfunction is primarily due to patients' impaired controlled processing of semantic information, rather than degradation of their semantic memory knowledge or automatic associative processes. The first hypothesis will be tested in experiments 1 & 2. Experiment one will employ the Penn Word Recognition Test (PWRT) which will allow us to replicate previous Positron Emission Tomography findings that impaired episodic memory is related to LIFG dysfunction during word encoding and retrieval. Experiment 2 will employ a shallow/deep word encoding and recognition paradigm that will permit us to test the role of self-generated organizational strategies in the semantic processing difficulties and related LIFG dysfunction in schizophrenia. The second primary hypothesis will be tested in the final two experiments. Experiment 3 will employ a cued semantic verbal fluency paradigm that will allow us to investigate the effect of reducing controlled processing demands on verbal fluency and LIFG function. The final experiment will use an uncued verbal fluency design that will permit a trial-by-trial examination of the effect of controlled versus automatic processing on LIFG function. This series of studies promises to uncover fundamental mechanisms of impaired semantic processing and related episodic memory and LIFG deficits in schizophrenia. Establishing this mechanism will lay the groundwork for future imaging studies and can help provide a rationale for developing cognitive interventions designed to remediate semantic processing and verbal memory deficits in schizophrenia in order to improve functional outcome.

描述（由申请人提供）：拟议研究的目标是 使用功能磁共振成像 (fMRI) 检验两个主要假设 关于精神分裂症记忆障碍的本质。第一个是 精神分裂症患者的情景记忆受损与语义功能障碍有关 处理，反映为未能激活左额下回（LIFG） 在文字编码和识别过程中。第二个假设是，这个 LIFG 功能障碍主要是由于患者的控制加工能力受损 语义信息，而不是语义记忆的退化 知识或自动联想过程。 第一个假设将在实验 1 和 2 中得到检验。实验 1 将 采用宾夕法尼亚州单词识别测试（PWRT），这将使我们能够复制 先前的正电子发射断层扫描发现情景记忆受损是 与单词编码和检索过程中 LIFG 功能障碍有关。实验2 将采用浅/深的单词编码和识别范式 允许我们测试自我生成的组织策略在 精神分裂症的语义处理困难和相关的 LIFG 功能障碍。 第二个主要假设将在最后两个实验中得到检验。 实验 3 将采用提示语义言语流畅性范式，该范式将 让我们能够研究减少受控处理需求的影响 语言流畅性和 LIFG 功能。最终的实验将使用无提示的 语言流利度设计，允许对语言进行逐次试验的检查 受控处理与自动处理对 LIFG 功能的影响。 这一系列研究有望揭示受损的基本机制 语义处理以及相关的情景记忆和 LIFG 缺陷 精神分裂症。这一机制的建立，将为今后的工作奠定基础。 成像研究可以帮助提供发展认知能力的基本原理 旨在修复语义处理和言语记忆的干预措施 精神分裂症的缺陷，以改善功能结果。