POST CONCUSSIVE SYMPTOMS: CHILDREN WITH MILD HEAD INJURY

脑震荡后症状：头部轻度受伤的儿童

• 批准号: 6637989
• 负责人: KEITH O YEATES
• 金额: $ 78.3万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-24 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6637989
• 关键词: academic achievement; adolescence (12-20); behavior disorders; behavior test; brain injury; child (0-11); clinical research; cognition; family structure /dynamics; functional ability; head /neck injury; human subject; interview; magnetic resonance imaging; mood disorders; musculoskeletal injury; neuropsychological tests; prognosis; quality of life; sign /symptom; stress management

Children and parents frequently report a variety of symptoms following mild closed-head injuries (CHI). These post-concussive symptoms often occur in the absence of any objective evidence of brain trauma and despite substantial recovery on standardized cognitive testing. Debate therefore continues regarding the determinants and consequences of post-concussive symptoms following mild CHI. The specific aims of the proposed study are to examine the (1) natural history, (2) prediction, and (3) consequences of post-concussive symptoms in children with mild CHI. The study will involve 200 8 to 15 year old children with mild CHI and 100 with mild orthopedic injuries not involving the head in a concurrent cohort/prospective research design. The children and their families will be assessed four times during the first year post-injury (i.e., at 1 week, 1 month, 3 months, and 12 months post-injury). Post-concussive symptoms will be assessed using rating scales and interviews, with both children and parents as informants. Predictors of post-concussive symptoms will include injury characteristics, cognitive abilities, and non-injury related child and family variables. Outcomes to be assessed include school performance, health utilization, and other aspects of child and family functioning. The study will examine three major hypotheses: (1) Children with mild CHI will display more post-concussive symptoms than children with mild orthopedic injuries, although group differences in incidence are expected to vary as a function of symptom type and time since injury; (2) The incidence of post-concussive symptoms will be related to (a) injury characteristics, (b) the extent to which the injury results in impairment in cognitive performance, and (c) non-injury related child and family factors. These relationships again are expected to vary as a function of symptom type and time since injury; and (3) Severe post-concussive symptoms will be associated with more child disability. The study will result in a clearer understanding of the roles that injury characteristics, post-injury cognitive status, and non-injury related factors play in the onset and persistence of post-concussive symptoms following mild CHI in children and adolescents. The study also will provide insights into the functional consequences of those symptoms for children. The findings will help resolve the scientific controversy regarding the outcomes associated with mild CHI, and will assist physicians and other health care providers in identifying the sequelae of mild CHI and managing them effectively.

儿童和家长经常报告各种症状 轻度闭合性头部损伤 (CHI) 后。这些脑震荡后症状通常 发生在没有任何脑外伤客观证据的情况下，尽管 标准化认知测试的显着恢复。因此争论 继续讨论脑震荡后的决定因素和后果 轻度气后出现的症状。拟议研究的具体目标是 检查 (1) 自然历史、(2) 预测和 (3) 后果 轻度 CHI 儿童的脑震荡后症状。该研究将涉及 200 8 至 15 岁患有轻度 CHI 的儿童和 100 名患有轻度骨科损伤的儿童 不让负责人参与并行队列/前瞻性研究设计。这 儿童及其家人在第一年将接受四次评估 受伤后（即受伤后 1 周、1 个月、3 个月和 12 个月）。 将使用评级量表和访谈来评估脑震荡后症状， 儿童和家长均作为线人。脑震荡后的预测因素 症状包括损伤特征、认知能力和 非伤害相关的儿童和家庭变量。需要评估的结果包括 学校表现、健康利用以及儿童和家庭的其他方面 发挥作用。该研究将检验三个主要假设：(1) 轻度 CHI 患者比轻度 CHI 患者表现出更多的脑震荡后症状 骨科损伤，尽管预计发病率存在群体差异 随症状类型和受伤后时间的变化而变化； (2)发生率 脑震荡后症状与 (a) 损伤特征、(b) 伤害导致认知能力受损的程度，以及 (c) 非伤害相关的儿童和家庭因素。这些关系又是 预计会随着症状类型和受伤后时间的变化而变化；和（3） 严重的脑震荡后症状将导致更多的儿童残疾。 该研究将使人们更清楚地了解伤害的作用 特征、损伤后认知状态和非损伤相关因素 轻度脑震荡后症状的发生和持续 儿童和青少年的 CHI。该研究还将提供有关以下方面的见解： 这些症状对儿童的功能性影响。研究结果将有助于 解决有关轻度相关结果的科学争议 CHI，并将协助医生和其他医疗保健提供者识别 轻度 CHI 的后遗症并对其进行有效管理。