CORE--CONTRACTILITY

核心——收缩性

• 批准号: 6592107
• 负责人: JOHN Arthur FAULKNER
• 金额: $ 25.46万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-15 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592107
• 关键词: aging; biomedical facility; biotechnology; data collection methodology /evaluation; fiber cell; genetically modified animals; laboratory mouse; measurement; mechanical pressure; muscle contraction; muscular dystrophy; myofibrils; statistics /biometry; striated muscles

The purpose of the Contractility Core is to provide collaborating investigators in the Program Project with reliable and valid measures of the contractile properties of whole striated muscles and of strips of diaphragm muscle fibers, statistical analysis of the data, and interpretation of the structure-function relationships. The Core will also provide opportunities for instruction and training for faculty and trainees who wish to learn the techniques. Muscle fibers when activated attempt to contract or shorten. Whether an activated myofiber shortens, stays at the same length or is stretched depends on the interaction between the force developed and the load. For striated muscle, contractility is defined as the capability of muscle fibers to develop force during fixed length or isometric contractions, during shortening or miometric contractions, and during lengthening or pliometric contractions. Our working hypothesis is that contractility of striated muscles is a complex phenomenon and the provision of reliable and valid measurements requires sophisticated equipment and highly trained muscle mechanicists to make the measurements and analyze and interpret the results. Consequently, to test hypothesis relating the underlying mechanisms of the reduced contractility of striated muscles in diseased and old animals rigorously, a Contractility Core is a necessity. Impairments during each of the three types of contraction may occur at any age due to injury or disease or as an intractable concomitant of aging. The impairments in contractility, whether due to injury, disease, or old age, limit the activities of daily living and reduce the quality of life, particularly for the sick and the elderly.

收缩核心的目的是提供合作 计划项目中的调查人员可靠 整条条纹肌肉和条带的收缩特性 diaphragm肌肉纤维，数据的统计分析以及 结构功能关系的解释。核心也将 为教师提供教学和培训的机会 希望学习技术的学员。激活时肌肉纤维 尝试收缩或缩短。激活的肌纤维是否缩短， 保持相同长度或拉伸取决于相互作用 在发育的力和负载之间。对于条纹肌肉， 收缩力被定义为肌肉纤维的能力 固定长度或等距收缩期间的力，缩短或 MITOMETRICTRICTRICTRICRAINCONT，以及在延长或稳定收缩期间。 我们的工作假设是，横纹肌肉的收缩力是 复杂现象和提供可靠和有效的测量 需要复杂的设备和训练有素的肌肉技工才能 进行测量并分析和解释结果。最后， 测试有关降低的基本机制的假设 严格的患病和老动物中条纹肌肉的收缩力， 收缩核心是必要的。三个中的每一个 由于受伤或疾病或AS，任何年龄的收缩类型可能发生 衰老的棘手伴随。收缩性障碍， 无论是由于受伤，疾病还是老年，都会限制每日活动 生活并降低生活质量，特别是对于病人和病人 老年。