SOFT XRAY MAGNETIC CIRCULAR DICHROISM OF PARAMAGNETIC BIOLOGICAL SYSTEMS

顺磁生物系统的软X射线磁圆二向色性

• 批准号: 6658645
• 负责人: Stephen P. Cramer
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6658645
• 关键词: biomaterials; biomedical resource; enzymes; proteins; spectrometry; structural biology

We would like to use our ultra-low temperature XMCD apparatus to examine the magnetic/electronic properties of complex biological samples. Although this technique is relatively new, we have already obtained data which shows the strong feasibility of the experiments. With our apparatus, we can reach fields as high as 6 Tesla, with a temperature of around .5K, or we can use our new rapid-sweep magnet which can go as high as 2 Tesla, with less than 130 mK. Using the beamline 5 EPU, we have obtained excellent results and would like to further that work. Since many complex metalloproteins are involved in important biological redox reactions, knowledge of their magnetic and electronic properties is important for a complete understanding of the enzymatic function.

我们想使用我们的超低温 XMCD 设备 检查复杂生物的磁/电子特性 样品。 虽然这项技术相对较新，但我们已经 获得的数据表明实验具有很强的可行性。 使用我们的设备，我们可以到达高达 6 特斯拉的磁场， 温度约为 0.5K，或者我们可以使用我们的新型快速扫描磁铁 其能量可高达 2 Tesla，且小于 130 mK。 使用 beamline 5 EPU，我们已经获得了优异的结果，并希望 进一步开展这项工作。 由于许多复杂的金属蛋白参与 重要的生物氧化还原反应，其磁性和 电子特性对于全面了解电子特性非常重要 酶的功能。