Core--Training

核心--培训

• 批准号: 6577825
• 负责人: Isaac I Wirgin
• 金额: $ 16.41万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6577825
• 关键词: biomedical facility; environmental toxicology; hazardous substances; science education; training

Chemical contaminants found at Superfund sites and in their leachates may play a significant role in the causation of human disease and in the deterioration of ecosystem health. Thus, such disease and ecological degradation is preventable to the extent that such factors can be identified and either removed from the environment or counteracted. Recognition of this possibility requires intensified efforts to identify the causal factors, to determine those conditions which modulate their bioavailabilities, to elucidate their mechanisms of action and to formulate appropriate measures for blocking or reversing their effects. The purpose of this Program is to provide training to prepare scientists for active and productive careers in environmental toxicology with interdisciplinary emphases on environmental engineering, bioremediation, ecology, and biomedical research. The objective is to prepare the trainees to plan, conduct, and interpret toxicological studies which are appropriate to specific scientific issues regarding the fate and effects of Superfund contaminants on human and wildlife populations. The scope of this program is broad. For example, trainees will be provided with backgrounds enabling them to study genetic and epigenetic factors which impact variation in susceptibilities to environmentally-induced disease in humans and in fish by metals and aromatic hydrocarbons and to understand those factors which influence bioavailabilities of these contaminants in ecosystems. The program provides for two predoctoral (Ph.D.) And four internship positions.

在超级基金场地及其渗滤液中发现的化学污染物可能在导致人类疾病和生态系统健康恶化方面发挥重要作用。因此，只要能够识别这些因素并将其从环境中消除或抵消，就可以预防此类疾病和生态退化。认识到这种可能性需要加紧努力，以确定因果因素，确定调节其生物利用度的条件，阐明其作用机制，并制定适当的措施来阻止或逆转其影响。该计划的目的是提供培训，为科学家在环境毒理学领域从事积极和富有成效的职业做好准备，重点是环境工程、生物修复、生态学和生物医学研究的跨学科。目的是让学员做好计划、进行和解释毒理学研究的准备，这些研究适合有关超级基金污染物对人类和野生动物种群的命运和影响的具体科学问题。该计划的范围很广泛。例如，将为学员提供背景知识，使他们能够研究影响人类和鱼类对金属和芳香烃环境诱发疾病的敏感性变化的遗传和表观遗传因素，并了解影响这些污染物在生态系统中生物利用度的因素。该计划提供两个博士前（Ph.D.）和四个实习职位。