Increasing screening in families with colorectal cancer

加强对结直肠癌家族的筛查

• 批准号: 6546228
• 负责人: SUSAN M RAWL
• 金额: $ 15.05万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6546228
• 关键词: cancer risk; clinical research; disease /disorder prevention /control; family; genetic susceptibility; health behavior; human subject; interview; long term survivor; rectum neoplasms

DESCRIPTION (provided by applicant): First-degree relatives of colorectal cancer (CRC) survivors have a two- to threefold increased risk of developing the same disease. Screening which leads to removal of precancerous polyps has been shown to decrease CRC incidence by 75-90%. Despite their increased risk, rates of participation in CRC screening among first-degree relatives are low. Tailored print interventions which are based on theories of behavior change have demonstrated considerable promise as interventions that motivate people to change health behaviors. The primary purpose of the proposed study is to develop and test the readership, relevance, and satisfaction of a theoretically-based tailored print intervention designed to increase participation in CRC screening among first-degree relatives of CRC survivors. A secondary purpose is to estimate the effect size of the tailored print intervention through comparison with a generic print intervention. The tailored print intervention will contain messages that are individually tailored for each participant based on baseline assessment of their individual demographics, CRC risk factors, health beliefs (perceived risk, benefits, barriers, self-efficacy), and stages of change for CRC screening. This preliminary efficacy study contrasts groups of first-degree relatives who will be randomly assigned to receive the tailored print intervention or the generic print intervention. Participants will be 220 first-degree relatives referred by CRC survivors. Data will be collected via structured telephone interviews at baseline, one week post-intervention, and three months post-baseline. Assessments of readership, relevance, and satisfaction with the print interventions will conducted one week post-intervention. Comparisons between tailored and generic interventions on readership relevance and satisfaction will be made using chi-square tests of independence. Preliminary effects of the interventions on knowledge, perceived risk, benefits, barriers, and self-efficacy at three months will be assessed using ANCOVA models. Screening participation will be assessed in two ways; coverage and compliance. Intervention effects on coverage and compliance will be estimated with logistics models adjusting for each demographic, family history, and index patient characteristics. Transition probabilities for stage of change will be calculated separately for the intervention groups for each screening test.

描述（由申请人提供）：结直肠癌 (CRC) 幸存者的一级亲属患相同疾病的风险增加两到三倍。切除癌前息肉的筛查已被证明可将 CRC 发病率降低 75-90%。尽管风险增加，但一级亲属参与结直肠癌筛查的比例很低。基于行为改变理论的定制印刷干预措施已显示出作为激励人们改变健康行为的干预措施的巨大前景。拟议研究的主要目的是开发和测试基于理论的定制印刷干预措施的读者群、相关性和满意度，该干预措施旨在提高 CRC 幸存者一级亲属对 CRC 筛查的参与度。第二个目的是通过与通用印刷干预进行比较来估计定制印刷干预的效果大小。定制的印刷干预措施将包含根据每个参与者的个人人口统计、CRC 风险因素、健康信念（感知风险、益处、障碍、自我效能）和 CRC 筛查变化阶段的基线评估为每个参与者量身定制的信息。这项初步功效研究对一级亲属进行了对比，这些亲属将被随机分配接受定制印刷干预或通用印刷干预。参与者将是 CRC 幸存者推荐的 220 名一级亲属。将在基线、干预后一周和基线后三个月通过结构化电话访谈收集数据。对印刷干预措施的读者群、相关性和满意度的评估将在干预后一周进行。将使用独立性卡方检验来比较针对读者相关性和满意度的定制干预措施和通用干预措施。将使用 ANCOVA 模型评估三个月后干预措施对知识、感知风险、收益、障碍和自我效能的初步影响。筛选参与度将以两种方式进行评估；覆盖范围和合规性。将通过根据每个人口统计、家族史和指标患者特征进行调整的后勤模型来估计干预措施对覆盖范围和依从性的影响。将针对每个筛选测试的干预组单独计算变化阶段的过渡概率。