TOTAL SYNTHESIS OF SCABRONINE A

SCABRONINE A 的全合成

• 批准号: 6477292
• 负责人: GREGORY B DUDLEY
• 金额: $ 2.03万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-01 至 2002-06-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477292
• 关键词: chemical synthesis; diterpenes; nerve growth factors; stereochemistry; stimulant /agonist; chemical synthesis; diterpenes; nerve growth factors; stereochemistry; stimulant /agonist

This proposal outlines a strategy for the enantioselective synthesis of (-)- scarbronine A, a complex diterpenoid natural product. The scabronine compounds are potent stimulators of nerve growth factor-synthesis, making them potential therapeutic agents for a variety of nervous system disorders. The proposed strategy utilizes a novel coupling annulation to assemble the seven-membered ring.

该提议概述了（ - ） - 炎热的二萜天然产物的对映选择性合成的策略。肩ca骨化合物是神经生长因子合成的有效刺激剂，使它们成为各种神经系统疾病的潜在治疗剂。拟议的策略利用新型的耦合环状来组装七元环。