CLINICAL NMR STUDIES AT 41T--A RESEARCH RESOURCE

41T 的临床 NMR 研究——研究资源

基本信息

批准号：
6363980
负责人：
DONALD B TWIEG
金额：
$ 65.92万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2003-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6363980
关键词：
biomedical equipment resource biomedical resource method development nuclear magnetic resonance spectroscopy

项目摘要

Throughout the development of in vivo NMR spectroscopy and imaging, there has been a push towards the utilization of higher field strengths and their inherent advantages of increases SNR and spatial and spectral resolution. However, only recently has it been demonstrated that the technical hurdles associated with high field NMR studies of humans can be overcome to accrue these advantages. This demonstration of the advantages of high field human NMR has in turn fueled the growth of high field (3 and T) systems. The majority of the users of these systems have focused their efforts on functional imaging of brain, with significantly less effort expended on the development and application of spectroscopic imaging, quantitative imaging and cardiac imaging into clinically useful protocols. To fully utilize the advantages of high field NMR in these areas, significant technological development and validation in meaningful clinical studies must occur. Therefore, the overall goal of this proposal is to develop a high field clinical NMR spectroscopy and imaging research resource. To achieve this goal we will focus on the development and implementation of : 1) advanced and novel methods to acquire unique data (such as the TA cycle rate, or ultra high temporal and spatial resolution functional images) which are either not possible or not routinely available on most commercial systems (both high and low field) and 2) enhance our ongoing clinical collaborations with novel methods for quantitative imaging and spectroscopy, thereby extending the state of the art in clinical NMR studies. Specifically, we will: 1) develop new spectroscopic imaging measurement to acquire ultra high redolution spectroscopic images of metabolites and map the TCA cycle rate: 2) improve the state of the art in rapid functional imaging through novel approaches of spiral scan imaging: 3) extend the current state of the art in high field imaging to permit quantitative imaging and its application in patients; 4) develop and implement clinically useful cardiac imaging methods; and 5) provide a common resource for the development of sophisticated metabolic modeling, experimental design and analysis software tools fro these protocols. These goals are intended to advance the state of the art in high field imaging and spectroscopy from a research curiousity to a powerful and clinically viable investigation tool.

在体内核磁共振波谱和成像的整个发展过程中，人们一直在推动利用更高的场强以及它们提高信噪比和空间和光谱的固有优势解决。然而，直到最近才被证明，与人类高场核磁共振研究相关的技术障碍可以克服这些困难才能获得这些优势。此次演示的高场人体核磁共振的优势反过来又推动了高场核磁共振的发展场（3 和 T）系统。这些系统的大多数用户他们将精力集中在大脑功能成像上显着减少在开发和应用上花费的精力光谱成像、定量成像和心脏成像临床上有用的方案。充分发挥高水平的优势这些领域的现场核磁共振、重大技术发展和必须进行有意义的临床研究验证。因此，该提案的总体目标是开发高场临床 NMR 光谱和成像研究资源。为了实现这个目标我们将重点开发和实施：1）先进和获取独特数据的新方法（例如 TA 周期率，或超高时间和空间分辨率功能图像）要么不可能，要么在大多数商业上通常不可用系统（高场和低场）和 2) 增强我们正在进行的临床与定量成像的新方法合作光谱学，从而扩展了临床 NMR 的最新技术研究。具体来说，我们将：1）开发新的光谱成像测量以获得超高分辨率光谱图像代谢物并绘制 TCA 循环率图：2) 提高现有技术水平通过螺旋扫描的新方法进行快速功能成像成像：3）将高场成像的当前技术水平扩展到允许定量成像及其在患者中的应用； 4）开发并实施临床上有用的心脏成像方法； 5) 提供复杂代谢发展的共同资源建模、实验设计和分析软件工具协议。这些目标旨在推进最先进的技术高场成像和光谱学从研究好奇心到强大且临床可行的调查工具。