CLINICAL NMR STUDIES AT 41T--A RESEARCH RESOURCE

41T 的临床 NMR 研究——研究资源

基本信息

批准号：
6363980
负责人：
DONALD B TWIEG
金额：
$ 65.92万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-03-01 至 2003-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6363980
关键词：
biomedical equipment resource biomedical resource method development nuclear magnetic resonance spectroscopy

项目摘要

Throughout the development of in vivo NMR spectroscopy and imaging, there has been a push towards the utilization of higher field strengths and their inherent advantages of increases SNR and spatial and spectral resolution. However, only recently has it been demonstrated that the technical hurdles associated with high field NMR studies of humans can be overcome to accrue these advantages. This demonstration of the advantages of high field human NMR has in turn fueled the growth of high field (3 and T) systems. The majority of the users of these systems have focused their efforts on functional imaging of brain, with significantly less effort expended on the development and application of spectroscopic imaging, quantitative imaging and cardiac imaging into clinically useful protocols. To fully utilize the advantages of high field NMR in these areas, significant technological development and validation in meaningful clinical studies must occur. Therefore, the overall goal of this proposal is to develop a high field clinical NMR spectroscopy and imaging research resource. To achieve this goal we will focus on the development and implementation of : 1) advanced and novel methods to acquire unique data (such as the TA cycle rate, or ultra high temporal and spatial resolution functional images) which are either not possible or not routinely available on most commercial systems (both high and low field) and 2) enhance our ongoing clinical collaborations with novel methods for quantitative imaging and spectroscopy, thereby extending the state of the art in clinical NMR studies. Specifically, we will: 1) develop new spectroscopic imaging measurement to acquire ultra high redolution spectroscopic images of metabolites and map the TCA cycle rate: 2) improve the state of the art in rapid functional imaging through novel approaches of spiral scan imaging: 3) extend the current state of the art in high field imaging to permit quantitative imaging and its application in patients; 4) develop and implement clinically useful cardiac imaging methods; and 5) provide a common resource for the development of sophisticated metabolic modeling, experimental design and analysis software tools fro these protocols. These goals are intended to advance the state of the art in high field imaging and spectroscopy from a research curiousity to a powerful and clinically viable investigation tool.

在整个体内NMR光谱和成像的整个过程中，一直在努力利用更高的场优势它们的固有优势增加了SNR，空间和光谱解决。但是，直到最近才证明与人类的高领域NMR研究相关的技术障碍可以要克服这些优势。这个关于高场的优势反过来促进了高的增长字段（3和T）系统。这些系统的大多数用户将他们的精力集中在大脑的功能成像上，在开发和应用方面花费的努力要少得多光谱成像，定量成像和心脏成像临床上有用的方案。充分利用高的优势这些领域的现场NMR，重要的技术发展和必须在有意义的临床研究中进行验证。因此，该建议的总体目标是开发高领域的临床NMR 光谱和成像研究资源。为了实现这一目标，我们将重点介绍：1）高级和获取独特数据的新方法（例如TA周期率，或超高的时间和空间分辨率功能图像）大多数商业都无法或不可用系统（高场和低场）和2）增强我们正在进行的临床与新颖方法进行定量成像和合作光谱法，从而扩展了临床NMR的最新技术研究。具体来说，我们将：1）开发新的光谱成像获取超高恢复光谱图像的测量代谢物并映射TCA周期率：2）改善最新技术状态在快速功能成像中，通过螺旋扫描的新方法成像：3）将高场成像中的艺术当前状态扩展到允许定量成像及其在患者中的应用； 4）发展并实施临床上有用的心脏成像方法； 5）提供发展代谢的共同资源这些建模，实验设计和分析软件工具从这些协议。这些目标旨在提高最新技术的状态从研究好奇到一个高田间成像和光谱功能强大且临床上可行的调查工具。