LORAZEPAM INDUCED COGNITIVE IMPAIRMENT ON TASK PERFORMANCE IN ADULTS

劳拉西泮导致成人任务表现认知障碍

• 批准号: 2478532
• 金额: $ 2.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2478532
• 关键词: accidents; age difference; balance; clinical research; cognition; drug adverse effect; human old age (65+); human subject; lorazepam; young adult human (21-34)

In order to determine the relationship between psychotropic drug use and falls in older adults, we gave 2 mg of lorazepam to healthy young (n=9, mean age 24) and older (n=8, mean age 71) females in a double blind, placebo-controlled experiment. The old had disproportionately greater drug-induced decrements in stepping accuracy and cognitive impairment, suggesting a possible mechanism for drug-induced falls.

为了确定精神药物使用与精神药物之间的关系 在老年人跌倒时，我们给健康年轻人服用 2 毫克劳拉西泮（n=9， 平均年龄 24）和年龄较大（n=8，平均年龄 71）的女性，采用双盲法， 安慰剂对照实验。 老年人的体力要大得多 药物引起的迈步准确性下降和认知障碍， 提示药物引起跌倒的可能机制。