Blood-Brain-CSF Barriers, CNS Homeostasis, Drug Delivery

血脑脑脊液屏障、中枢神经系统稳态、药物输送

• 批准号: 6550284
• 负责人: Martha E O'Donnell
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6550284
• 关键词: blood brain barrier; brain; central nervous system; drug delivery systems; homeostasis; meeting /conference /symposium; travel

This proposal is a request for funds toward the support of a Gordon Research Conference to be held in July 2002. The intended meeting is the second Gordon Research Conference on Barriers of the Central Nervous System. This Gordon Research Conference was initiated as a catalyst for interaction among researchers from a variety f disciplines working on issues of blood-brain- and blood-CSF barriers in health disease. Research in this area is already leading to development of new therapeutic approaches for th treatment of stroke, head trauma, neurodegeneration, brain inflammation and brain tumors, to name a fe3w. Although portions of these areas of investigation are represented at several national and international research meetings, there have been few opportunities for scientists working in the field to come together with a specific concentrated focus on issues related to barriers of the CNS. The subtitle of the upcoming second Barriers of the CNS Gordon Research Conference is "Blood-Brain CSF barriers, CNS Homeostasis and Drug Delivery to the Brain". The specific focus of this conference will include discussion of a number of the problems and tissues faced by the Pharmaceutical industry in targeting therapeutic drugs to the CNS as well as discussion of broader current major developments of the blood- brain-barrier and blood-CSF barrier field. Most of these problems concern overcoming the blood-brain barrier to drugs. To this end a number of eminent scientists from academia and from the pharmaceutical industry, are being brought together for an exciting "leading edge" meeting. The intention is to foster the development of new ideas and their application to fundamental knowledge and the treatment of human and animal disease. Speakers have been selected on the basis of their eminence in the field and their communication skills. TO this end they are drawn from a wide geographical background. Chairs of the sessions have been selected on the basis of their considerable eminence and experience in the field and a known ability to communicate and debate well. In addition the presentation of posters is being vigorously encouraged especially by young postdoctoral and research students. It is expected that a considerable proportion of any NIH grant will be used to fund the attendance of young scientists and chairs. It is also intended to have three open workshops/debates during the meeting. One is already in place on "Microdialysis". The maximum permitted attendance at this meeting is 150 scientists.

该提案是为支持将于 2002 年 7 月举行的戈登研究会议而请求的资金。预定的会议是第二届关于中枢神经系统障碍的戈登研究会议。这次戈登研究会议的发起是为了促进来自不同学科的研究人员之间的互动，研究健康疾病中的血脑和血脑脊液屏障问题。该领域的研究已经导致开发出新的治疗方法，用于治疗中风、头部外伤、神经退行性疾病、脑炎症和脑肿瘤等。尽管这些研究领域的部分内容出席了多个国家和国际研究会议，但该领域工作的科学家很少有机会聚集在一起，专门关注与中枢神经系统障碍相关的问题。即将举行的第二届中枢神经系统戈登研究会议障碍的副标题是“血脑脑脊液障碍、中枢神经系统稳态和大脑药物输送”。本次会议的具体重点将包括讨论制药行业在将治疗药物靶向中枢神经系统方面面临的许多问题和组织，以及讨论血脑屏障和血脑脊液屏障的当前主要发展场地。这些问题大多涉及克服药物的血脑屏障。为此，来自学术界和制药行业的许多杰出科学家齐聚一堂，召开令人兴奋的“前沿”会议。目的是促进新思想的发展及其在基础知识以及人类和动物疾病治疗中的应用。发言人是根据他们在该领域的杰出地位和沟通技巧来选择的。为此，他们来自广泛的地理背景。会议主席的选择是基于他们在该领域的杰出地位和经验以及众所周知的良好沟通和辩论能力。 此外，特别是年轻博士后和研究生也大力鼓励海报展示。预计 NIH 拨款的相当一部分将用于资助年轻科学家和主席的出席。会议期间还计划举办三场公开研讨会/辩论。其中一项已经在“微透析”上到位。出席本次会议的最多科学家人数为 150 名。