Making and Breaking Bonds with Radicals and Anions

与自由基和阴离子形成和断裂键

• 批准号: 1688241
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1688241
• 关键词: Making; Breaking; Bonds; Radicals; Anions

This project will study coupling reactions forming C-C and C-X (X = heteroatom) bonds, without palladium catalysts. This has economic advantages as these catalysts are costly. There are also environmental advantages: (i) environmentally damaging mining of palladium will not be needed to provide catalysts for the coupling reactions and (ii) contamination of pharmaceutical intermediates by hazardous palladium residues will be avoided, thereby avoiding costly purifications. The couplings will be facilitated under basic conditions by the presence of bespoke organic additives, leading to a potentially useful new approach in synthesis.

该项目将研究构成C-C和C-X（X =杂原子）键的耦合反应，而无需钯催化剂。由于这些催化剂的昂贵，因此具有经济优势。也有环境优势：（i）将不需要为耦合反应提供催化剂的环境破坏采矿，并且（ii）将避免危险的钯残基对药物中间体的污染，从而避免使用危险的污染物。耦合将在基本条件下通过定制有机添加剂的存在来促进耦合，从而导致一种潜在有用的合成方法。