GENETIC BASIS OF SYNDROME X ON THE ISLAND OF KOSRAE

科斯雷岛 X 综合征的遗传基础

• 批准号: 6381602
• 负责人: JEFFREY M FRIEDMAN
• 金额: $ 82.8万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381602
• 关键词: Pacific Islander; blood chemistry; clinical research; diabetes mellitus; electrocardiography; gene environment interaction; gene expression; gene interaction; genetic disorder; genetic mapping; genetic susceptibility; genotype; human genetic material tag; human population study; human subject; hypertension; linkage disequilibriums; lipid disorder; longitudinal human study; obesity; pathologic process; phenotype; polymerase chain reaction; statistics /biometry

DESCRIPTION (Adapted from investigator's abstract): This application proposes a series of genetic and clinical studies to elucidate the genetic basis of hypertension, obesity, diabetes and dyslipidemia. These diseases are often associated with one another and when they occur together they are referred to as Syndrome X. The basis for these disorders, which are principal causes of morbidity and mortality worldwide, is largely unknown. The incidence of obesity, hypertension, diabetes and dyslipidemia is increased on the Pacific Island of Kosrae. In studies completed in 1994, a medical evaluation was conducted and DNA was isolated from each of 2364 Kosraeans over the age 20, nearly the entire adult population. In this application, the investigators propose to complete this genetic study by applying modern methods in human genetics to map the genes that cause the components of Syndrome X. In addition, a follow-up clinical study will be performed on the entire population of the island over 16 years old. It is expected that this will add 1000 new participants.

描述（根据调查员的摘要改编）：此应用程序提出了 一系列遗传和临床研究，以阐明 高血压，肥胖，糖尿病和血脂异常。这些疾病通常是 彼此相关，当它们一起发生时 作为综合征X。这些疾病的基础，这是 全球发病率和死亡率在很大程度上是未知的。发病率 太平洋上的肥胖，高血压，糖尿病和血脂异常增加 科斯拉岛。在1994年完成的研究中，医学评估是 从20岁以上的2364名Kosraeans中分离出来并分离DNA， 几乎是整个成年人。在此应用程序中，调查人员 建议通过在人类中应用现代方法来完成这项遗传研究 遗传学以绘制引起综合征X成分的基因。此外， 将对整个人群进行后续临床研究 超过16岁的岛屿。预计这会增加1000个新 参与者。