THERMOACOUSTIC CT OF THE BREAST

乳房热声 CT

• 批准号: 6376112
• 负责人: ROBERT A KRUGER
• 金额: $ 69.87万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-03 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376112
• 关键词: MCF7 cell; athymic mouse; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; computed axial tomography; computer simulation; diagnosis design /evaluation; female; human subject; image enhancement; mammary gland; mammography; microwave radiation; radiowave radiation; thermography

DESCRIPTION (Adapted from Applicant's Abstract): During the previous funding period, reported having developed a new medical imaging paradigm called thermoacoustic CT (TCT). In its current implementation, TCT utilizes brief pulses of radio waves at 434 MHz to stimulate acoustic emissions in soft tissue. These sonic emissions are detected by an array of piezo-electric crystals and are recorded temporally following each of 250,000 individual RF pulses. From the recorded sonic emissions, patterns of radio-wave absorption within the soft tissue volume are reconstructed in three dimensions. The applicants reported having demonstrated good soft tissue differentiation in an excised porcine kidney, and we have successfully imaged breast cancer in vivo. The goal of the proposed research program is to better understand the underlying RF-absorption properties of soft tissue, and to improve the current TCT instrumentation for imaging the human breast. To these ends, the following specific aims will be pursued during the proposed three-year funding period: 1. Relate the properties of specific heart, volume thermal expansion and complex permittivity to TCT image contrast: 2. Relate bound water fraction to TCT image contrast; 3. Correlate the physiologic properties of different breast tumor cell lines with TCT image contrast; 4. Develop simulation tools to predict and validate TCT imaging performance in the breast; 5. Design, construct and test an improved TCT breast scanner; and 6. Perform retrospective TCT imaging on small groups of patients

描述（改编自申请人的摘要）：在上一次资助期间 期间，报告开发了一种新的医学成像范式，称为 热声CT (TCT)。在当前的实施中，TCT 使用简短的 434 MHz 无线电波脉冲刺激软体中的声发射 组织。这些声波发射由一系列压电传感器检测到 晶体并在 250,000 个单独 RF 中的每一个之后进行临时记录 脉冲。根据记录的声波发射，无线电波吸收模式 软组织体积内的三维重建。这 申请人报告称，已在一项研究中表现出良好的软组织分化能力。 切除猪肾，我们成功地对乳腺癌进行体内成像。 拟议研究计划的目标是更好地了解 软组织的潜在射频吸收特性，并改善电流 用于人类乳房成像的 TCT 仪器。为此，现提出如下 在拟议的三年供资期内将实现以下具体目标： 1. 将特定心脏的特性、体积热膨胀和复合体联系起来 介电常数与 TCT 图像对比度：2. 将结合水分数与 TCT 图像相关联 对比; 3. 关联不同乳腺肿瘤的生理特性 具有TCT图像对比的细胞系； 4. 开发模拟工具来预测和 验证乳房 TCT 成像性能； 5. 设计、构建和测试 改进的 TCT 乳房扫描仪； 6. 对患者进行回顾性 TCT 成像 小群患者