CYTOSINE ARABINOSIDE FOR MULTIFOCAL LEUKOENCEPHALOPATHY IN HIV INFECTION

阿糖胞苷治疗 HIV 感染引起的多灶性白质脑病

• 批准号: 6302836
• 负责人: COLIN D HALL
• 金额: $ 27.36万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6302836
• 关键词: 2'3' dideoxycytidine; 2'3' dideoxyinosine; AIDS therapy; HIV infections; antiviral agents; colony stimulating factor; cytosine arabinoside; human subject; human therapy evaluation; nervous system disorder chemotherapy; neuropsychological tests; progressive multifocal leukoencephalopathy; zidovudine

This Project will evaluate the effectiveness of cytosine arabinoside for treatment of biopsy proven progressive multifocal leukoencephalopathy in subjects with human immunodeficiency virus infection. A three arm study comparing best possible anti-retroviral therapy with either intravenous ARA-C therapy administered through an Ommaya reservoir. Twenty patients will be randomized to each arm of the study. The primary endpoint is death within 24 weeks. Secondary end points will be neurologic deterioration as indicated by neurologic examination and deterioration in Karnofsky Performance Scores.

该项目将评估阿糖胞苷的有效性 治疗活检证实的进行性多灶性白质脑病 患有人类免疫缺陷病毒感染的受试者。 三臂研究 比较最佳的抗逆转录病毒疗法与静脉注射疗法 ARA-C 疗法通过 Ommaya 储库进行。 二十名患者 将被随机分配到研究的每个组。 主要终点是 24 周内死亡。 次要终点是神经系统 神经系统检查和恶化表明恶化 在卡诺夫斯基表现评分中。