The first validation of personalised dosimetry for molecular radiotherapy using 3D printed organs - Invited resubmission.

首次验证使用 3D 打印器官进行分子放射治疗的个性化剂量测定 - 邀请重新提交。

基本信息

批准号：
ST/M004589/1
负责人：
David Matthew Cullen
金额：
$ 12.33万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=ST%2FM004589%2F1
关键词：
first validation personalised dosimetry molecular

项目摘要

With this grant we will develop the first system for accurately validating organ dose estimates for patients receiving cancer therapy using radioactive materials which target their tumours, known as Molecular Radiotherapy (MRT). Currently simple water filled cylinders or spheres of varying sizes are used to represent patient organs when testing the accuracy of measurements of radiation dose delivered to tumours and critical organs in a patients body. These cylinders are used as a calibration to convert the number of gamma rays detected in a SPECT gamma-camera system to an activity inside a patient's organ. Our current research has shown that this calibration method can actually result in organ dose estimates with systematic errors of up to 40%, preventing individualised patient treatments from being optimised. Consequently a significant number of patients do not currently receive the optimal therapy.By using realistic 3D printed models based on CT scans of patient organs we can accurately determine how well current commercial systems measure the dose to individual patient organs. This provides the first rigorous validation of these systems, a necessary requirement if the systems are to be used for all patient therapies. Our 3D printed models will also provide a much more accurate activity calibration, based on real organ geometries, for the SPECT scanner systems used to measure dose for MRT.Accurate MRT dose information is now considered very important in countries across Europe. Legislation now recommends accurate dosimetry for every patient receiving Molecular radiotherapy treatment. Our research will provide a new gold standard for assessing dosimetry systems used in clinical departments. This will highlight any weaknesses in current systems and in combination with our new realistic calibration factor measurements will allow the accuracy of dose measurements to be improved for all SPECT camera systems and MRT therapies.By establishing the accuracy of current dosimetry systems we will be able to provide a pathway to improve current commercial systems based on techniques from our recent research and future developments based on our 3D printed models. We are currently working with a leading provider of nuclear medicine workstation software who are supporting our work to validate their system. A rigorously validated commercial system has the potential to provide a significant improvement in the outcome of an estimated 201,00 MRT therapies performed annually in Europe.

通过这笔拨款，我们将开发第一个系统，用于准确验证接受癌症治疗的患者的器官剂量估计，该治疗使用针对肿瘤的放射性材料，称为分子放射治疗（MRT）。目前，在测试递送至患者体内的肿瘤和关键器官的辐射剂量测量的准确性时，使用不同尺寸的简单的充满水的圆柱体或球体来代表患者器官。这些圆柱体用于校准，将 SPECT 伽马相机系统中检测到的伽马射线数量转换为患者器官内的活动。我们目前的研究表明，这种校准方法实际上可能会导致器官剂量估计的系统误差高达 40%，从而阻碍个体化患者治疗的优化。因此，大量患者目前没有接受最佳治疗。通过使用基于患者器官 CT 扫描的真实 3D 打印模型，我们可以准确确定当前商业系统测量个体患者器官剂量的效果。这为这些系统提供了第一次严格的验证，如果系统要用于所有患者治疗，这是一个必要的要求。我们的 3D 打印模型还将根据真实的器官几何形状，为用于测量 MRT 剂量的 SPECT 扫描仪系统提供更准确的活动校准。现在，准确的 MRT 剂量信息在欧洲各国被认为非常重要。现在立法建议对每位接受分子放射治疗的患者进行准确的剂量测定。我们的研究将为评估临床部门使用的剂量测定系统提供新的黄金标准。这将突出当前系统中的任何弱点，并与我们新的现实校准因子测量相结合，将提高所有 SPECT 摄像系统和 MRT 治疗的剂量测量的准确性。通过建立当前剂量测定系统的准确性，我们将能够基于我们最近研究的技术和基于 3D 打印模型的未来开发，提供了改进当前商业系统的途径。我们目前正在与一家领先的核医学工作站软件提供商合作，他们支持我们验证其系统的工作。经过严格验证的商业系统有可能显着改善欧洲每年进行的约 201,00 例 MRT 治疗的结果。