Sub voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging

用于低剂量分子乳腺成像的碲化镉锌探测器中的亚体素位置识别

• 批准号: ST/S002723/1
• 负责人: Laura Joanne Harkness-Brennan
• 金额: $ 46.14万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FS002723%2F1
• 关键词: Sub; voxel; position; identification; Cadmium

This knowledge exchange project seeks to develop an optimised Cadmium Zinc Telluride (CZT) system for low dose molecular breast imaging (MBI). Breast cancer is the most common type of cancer in the UK, with 1 in 8 women developing the disease. Approximately 50% of women of screening age have mammographically dense breasts but conventional X-ray mammography has reduced diagnostic performance for these patients. This limitation can be overcome by using MBI, a technique in which a molecular tracer selectively targets malignant breast tissue to provide high-resolution functional images. Earlier diagnosis and more accurate staging of the disease using optimised MBI systems will potentially lead to better patient outcomes and reduced mortality rates. The proposed research will improve the imaging performance of MBI, which will increase the probability of detecting lesions in the breast. This will be based on exploiting our knowledge of how radiation interacts in the imaging system.

该知识交流项目旨在开发一种用于低剂量分子乳腺成像 (MBI) 的优化碲化镉锌 (CZT) 系统。乳腺癌是英国最常见的癌症类型，八分之一的女性患有这种疾病。大约 50% 达到筛查年龄的女性拥有乳房 X 光检查致密的乳房，但传统的 X 射线乳房 X 光检查降低了这些患者的诊断性能。这一限制可以通过使用 MBI 来克服，MBI 是一种分子示踪剂选择性靶向恶性乳腺组织以提供高分辨率功能图像的技术。使用优化的 MBI 系统进行早期诊断和更准确的疾病分期将有可能带来更好的患者治疗结果并降低死亡率。拟议的研究将提高 MBI 的成像性能，从而增加检测乳腺病变的概率。这将基于利用我们对辐射如何在成像系统中相互作用的知识。

项目成果

Characterisation of the charge collection properties in a segmented planar HPGe detector

分段平面 HPGe 探测器中电荷收集特性的表征

• DOI: 10.1016/j.nima.2020.164804
• 发表时间: 2021
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E

Development of the DEPICT system for gamma-ray imaging in molecular radiotherapy

分子放射治疗中伽马射线成像 DEPICT 系统的开发

• 发表时间: 2019
• 作者: McAreavey Lucy H.

Sub-voxel identification of gamma-ray interaction positions within a pixelated CZT detector through signal analysis

通过信号分析对像素化 CZT 探测器内的伽马射线相互作用位置进行亚体素识别

• DOI: 10.1016/j.nima.2022.167639
• 发表时间: 2023
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E

Simulation and validation of a planar HPGe detector signal database for use in pulse shape analysis

用于脉冲形状分析的平面 HPGe 探测器信号数据库的仿真和验证

• DOI: 10.1016/j.nima.2022.166641
• 发表时间: 2022
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E