Sub voxel position identification in Cadmium Zinc Telluride detectors for Low Dose Molecular Breast Imaging

用于低剂量分子乳腺成像的碲化镉锌探测器中的亚体素位置识别

• 批准号: ST/S002723/1
• 负责人: Laura Joanne Harkness-Brennan
• 金额: $ 46.14万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FS002723%2F1
• 关键词: Sub; voxel; position; identification; Cadmium

This knowledge exchange project seeks to develop an optimised Cadmium Zinc Telluride (CZT) system for low dose molecular breast imaging (MBI). Breast cancer is the most common type of cancer in the UK, with 1 in 8 women developing the disease. Approximately 50% of women of screening age have mammographically dense breasts but conventional X-ray mammography has reduced diagnostic performance for these patients. This limitation can be overcome by using MBI, a technique in which a molecular tracer selectively targets malignant breast tissue to provide high-resolution functional images. Earlier diagnosis and more accurate staging of the disease using optimised MBI systems will potentially lead to better patient outcomes and reduced mortality rates. The proposed research will improve the imaging performance of MBI, which will increase the probability of detecting lesions in the breast. This will be based on exploiting our knowledge of how radiation interacts in the imaging system.

这个知识交换项目旨在开发低剂量分子乳房成像（MBI）的优化镉卸尿剂（CZT）系统。乳腺癌是英国最常见的癌症类型，其中有八分之一的妇女患上了这种疾病。大约50％的筛查年龄女性具有乳腺乳房密集的乳房，但常规的X射线乳房摄影术减少了这些患者的诊断性能。可以通过使用MBI来克服这种限制，MBI是一种技术，其中分子示踪剂选择性地靶向恶性乳腺组织以提供高分辨率的功能图像。使用优化的MBI系统对疾病的较早诊断和更准确的分期可能会导致更好的患者结局和降低的死亡率。拟议的研究将改善MBI的成像性能，这将增加检测乳房病变的可能性。这将基于利用我们对辐射在成像系统中如何相互作用的了解。

项目成果

Characterisation of the charge collection properties in a segmented planar HPGe detector

分段平面 HPGe 探测器中电荷收集特性的表征

• DOI: 10.1016/j.nima.2020.164804
• 发表时间: 2021
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E

Development of the DEPICT system for gamma-ray imaging in molecular radiotherapy

分子放射治疗中伽马射线成像 DEPICT 系统的开发

• 发表时间: 2019
• 作者: McAreavey Lucy H.

Sub-voxel identification of gamma-ray interaction positions within a pixelated CZT detector through signal analysis

通过信号分析对像素化 CZT 探测器内的伽马射线相互作用位置进行亚体素识别

• DOI: 10.1016/j.nima.2022.167639
• 发表时间: 2023
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E

Simulation and validation of a planar HPGe detector signal database for use in pulse shape analysis

用于脉冲形状分析的平面 HPGe 探测器信号数据库的仿真和验证

• DOI: 10.1016/j.nima.2022.166641
• 发表时间: 2022
• 期刊: Accelerators, Spectrometers, Detectors and Associated Equipment
• 作者: Rintoul E