COLLABORATIVE PROGRAM IN BPD

BPD 合作项目

• 批准号: 6184292
• 负责人: JACQUELINE Jones COALSON
• 金额: $ 196.41万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-20 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184292
• 关键词: animal breeding; animal colony; baboons; bronchopulmonary dysplasia; cooperative study; data management; disease /disorder model; neonatal intensive care; pathologic process; premature infant animal; respiratory distress syndrome of newborn; tissue resource /registry

The overall goal of this cooperative research program is to develop a multi- institutional research effort to address the mechanisms of postnatal lung pathobiology that lead to chronic lung disease and to provide a unique resource center of prematurely delivered baboons with induced bronchopulmonary dysplasia (BPD) and chronic lung disease (CLD) to outstanding investigators from multiple institutions dedicated to sharing collaborative protocols and tissue specimens. In recent years, the original form of BPD described in the 1960's has become less common due to improvements in oxygenation and ventilatory strategies and the use of postnatal exogenous surfactant, and has been replaced by a less severe from of disease primarily in extremely small immature infants, called chronic lung disease of infancy (CLD). The baboon models of BPD and CLD are unique in the world; they develop disease that is very similar, if not identical, of human disease but in a controlled environment. The Southwest Foundation for Biomedical Research and the University of Texas Health Science Center at San Antonio have the breeding colony and the scientific personnel to support the proposed BPD Resource Core. The specific aims of the BPD Resource Core are: 1) To breed baboons to produce pregnancies of known gestational ages, and to delivery by caesarian section 100 timed pregnancies per year, to provide the premature infants that will be shared by multiple investigators. 2) To maintain these premature infant baboons in a neonatal intensive care environment for short periods of up to 14 days, utilizing several well-defined treatment protocols, and long-term outcomes in 1 to 2 month and 42 week survivors, the latter the baboon equivalent of a 2 year old human infant in whom alveolarization should be complete. 3) To provide tissue specimens taken at the time of delivery, during the animal's clinical course, and at necropsy in as ideal and timely a manner as possible, and tailored to each investigator's needs. 4) To provide a Data Management Core for animal information retrieval. This U-10 program brings together the enthusiasm and competence of established investigators with varying backgrounds and expertise who are committed to examining the various aspects of lung development and how, when interrupted, the fetus adapts to the extrauterine environment. It allows, at a national level, a continuing influx of outstanding scientists to address the major deficiencies in our knowledge concerning BPD/CLD.

该合作研究计划的总体目标是开展多机构研究工作，以解决导致慢性肺病的产后肺部病理学机制，并为患有诱发性支气管肺发育不良（BPD）和早产狒狒提供一个独特的资源中心。慢性肺病（CLD）来自多个机构的杰出研究人员致力于共享合作方案和组织标本。近年来，由于氧合和通气策略的改进以及产后外源性表面活性剂的使用，20世纪60年代描述的BPD原始形式已不再常见，并已被主要发生在极小未成熟婴儿中的不太严重的疾病所取代，称为婴儿慢性肺病（CLD）。 BPD和CLD的狒狒模型在世界上是独一无二的；它们所患的疾病与人类疾病非常相似，甚至完全相同，但都是在受控环境中进行的。西南生物医学研究基金会和圣安东尼奥德克萨斯大学健康科学中心拥有繁殖群和科学人员来支持拟议的 BPD 资源核心。 BPD 资源核心的具体目标是： 1) 繁殖狒狒以产生已知胎龄的怀孕，并每年通过剖腹产分娩 100 次定时怀孕，以提供将由多个研究人员共享的早产儿。 2) 使用几种明确的治疗方案，将这些早产婴儿狒狒在新生儿重症监护环境中维持长达 14 天的短时间，并在 1 至 2 个月和 42 周的幸存者（后者为狒狒）中获得长期结果相当于一个 2 岁的人类婴儿，其肺泡化应该是完全的。 3) 以尽可能理想和及时的方式提供在分娩时、动物临床过程中和尸检时采集的组织标本，并根据每个研究者的需要进行定制。 4) 为动物信息检索提供数据管理核心。该 U-10 项目汇集了具有不同背景和专业知识的知名研究人员的热情和能力，他们致力于检查肺部发育的各个方面以及胎儿在中断时如何适应宫外环境。它使得在国家层面上不断涌入杰出科学家来解决我们在 BPD/CLD 知识中的重大缺陷。