PHYSIOLOGICAL BASES OF OTOTRAUMATIC INSULT

耳外伤性侮辱的生理学基础

基本信息

批准号：
6286582
负责人：
Brenda Lee Lonsbury-Martin
金额：
$ 32.59万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-03-01 至 2006-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6286582
关键词：
acetylcholine cholinergic receptors clinical research cochlear nerve complementary DNA conditioning conductive hearing loss disease /disorder model ear efferent nerve genetic susceptibility human subject laboratory mouse laboratory rabbit microarray technology model design /development nerve threshold otoacoustic emission physiology polymerase chain reaction sensorineural hearing loss trauma

acetylcholine cholinergic receptors clinical research cochlear nerve complementary DNA conditioning conductive hearing loss disease /disorder model ear efferent nerve genetic susceptibility human subject laboratory mouse laboratory rabbit microarray technology model design /development nerve threshold otoacoustic emission physiology polymerase chain reaction sensorineural hearing loss trauma

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项目摘要

Description: The proposed studies focus on the contribution of the cochlear-efferent system in the susceptibility to noise and the phenomenon of "sound conditioning." Several hypotheses are proposed to determine whether the susceptibility of the ear can be experimentally manipulated through sound conditioning, if the cochlear-efferent system is involved in sound conditioning and whether auditory or systemic factors are involved in the process. In addition, the molecular bases of protection from sound-overexposure will be explored. The functional measure employed in the experiment is the 2f1-f2 DPOAE and its alteration by presentation of a pure tone presented to the opposite ear. The change in DPOAE with binaural stimulation is proposed as a measure of "efferent strength," which appears to vary among individual animals and humans. Three hypotheses are proposed. In the first, awake rabbits will be used as subjects to determine if the efferent system plays a role in 'sound conditioning', whether the effect is ear-specific and whether other systemic factors are involved. The second hypothesis tests the extent to which "sound conditioning" is apparent in mice that have varying susceptibility to noise-induced hearing loss. The third hypothesis tests whether susceptibility to hearing loss or the prevention from it is associated with specific molecules in the cochlea.

描述：拟议的研究重点是对噪声的敏感性和现象的耳蜗有效系统 “调理。”提出了几种假设来确定是否耳朵的敏感性可以通过声音实验操纵条件，如果人工耳蜗有效系统参与声音条件以及该过程中是否涉及听觉或系统因素。在此外，防止曝光的保护分子基础将是探索。实验中采用的功能度量是2F1-F2 DPOAE 并通过呈现纯正的语调来改变相反的语调耳朵。提出了用双耳刺激的DPOAE的变化作为量度 “传出力量”在单个动物和人类中似乎有所不同。提出了三个假设。首先，清醒的兔子将被用作受试者确定传出系统是否在声音中起作用条件' 涉及因素。第二个假设检验了“声音条件“在对具有不同敏感性的小鼠中显而易见噪声引起的听力损失。第三个假设检验是否敏感听力损失或预防与特定分子有关在耳蜗中。