PHYSIOLOGY AND GENETICS OF OBESITY

肥胖的生理学和遗传学

• 批准号: 6290189
• 负责人: JACK ADAM YANOVSKI
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290189
• 关键词: African American; adipose tissue; adrenocorticotropic hormone; basal metabolism; beta adrenergic receptor; bioenergetics; body composition; caucasian American; child (0-11); clinical research; corticotropin releasing factor; disease /disorder proneness /risk; epidemiology; genetics; glucose metabolism; glucose tolerance test; health behavior; human puberty; human subject; insulin sensitivity /resistance; leptin; lipid metabolism; longitudinal human study; noninsulin dependent diabetes mellitus; obesity; racial /ethnic difference

Many minority populations in the US have a markedly increased risk of obesity and its comorbid conditions, such as type 2 diabetes, hypertension, and cardiovascular disease, that contribute to substantially greater mortality. Much evidence suggests that the predictive risk factors and the therapeutic approaches for these comorbid conditions that are derived from the study of Caucasians may be less applicable to those of differing ethnicity or race. Effective prevention and treatment of these disorders requires a better understanding of their etiology. This unit investigates the genetic, physiologic, metabolic, and behavioral factors involved in determining weight regulation and body composition, with a special emphasis on pediatric and minority populations. Progress has been made in our longitudinal studies of body composition, energy expenditure, leptin, uncoupling proteins, insulin sensitivity and glucose disposal, which seek to characterize the timing and nature of factors that may contribute to the prevalence of obesity and its complications. These studies will aid in the rational development of approaches for the prevention and trea - obesity, race, diabetes mellitus, children, insulin, metabolism, weight, genetics, leptin, uncoupling proteins - Human Subjects

美国许多少数族裔人群的肥胖风险及其合并症的风险显着增加，例如2型糖尿病，高血压和心血管疾病，这会导致死亡率更大。大量证据表明，从对高加索人的研究中得出的这些合并症的预测危险因素和治疗方法可能不太适用于不同种族或种族的人。对这些疾病的有效预防和治疗需要更好地了解其病因。该单元研究了确定体重调节和身体组成涉及的遗传，生理，代谢和行为因素，并特别强调了小儿和少数群体。在我们对人体组成，能量消耗，瘦素，解偶联蛋白，胰岛素敏感性和葡萄糖处置的纵向研究中，取得了进展，这些研究旨在表征因素的时机和性质，这些因素可能有助于肥胖及其并发症的流行。这些研究将有助于合理发展预防和trea肥胖，种族，糖尿病，儿童，胰岛素，代谢，体重，遗传学，瘦素，解偶联蛋白的受试者 - 人类受试者 - 人类受试者