VANADYL CHELATES AS PROBES FOR PARAMAGNETIC MRI CONTRAST AGENTS

氧钒螯合物作为顺磁 MRI 造影剂的探针

• 批准号: 6120608
• 负责人: JOHN CHEN
• 金额: $ 0.81万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6120608
• 关键词: biomedical resource; computers; magnetic resonance imaging; radiology; technology /technique

The solvent proton longitudinal (spin-lattice) relaxation time (1/T1M) of a paramagnetic contrast agent is directly related to the image contrast in medical magnetic resonance imaging (MRI). There are two contributors to proton relaxation, known as inner sphere and outer sphere. Solomon and Bloembergen have shown that the inner sphere proton longitudinal relaxation time is dependent upon three factors, namely the rotational correlation time (R), the electronic spin-lattice relaxation time (S), and the lifetime of the water protons in the paramagnetic metal site (M). Outer-sphere relaxation has been found to depend on the correlation time of the solute and the solvent to diffuse apart () and again the electronic spin-lattice relaxation time. However, direct measurements of these components have not been easy to obtain. Nuclear magnetic relaxation dispersion (NMRD) can only provide estimates to the parameters mentioned above. In this study we report the successful employment of elect ron paramagnetic resonance (EPR), using vanadyl complexed to two different chelates (EDTA and DTPA) as spin probes, in direct measurements of the rotational correlation time. Furthermore, estimates derived from fitting nuclear magnetic relaxation dispersion (NMRD) profiles corroborate the EPR results obtained. This is an ongoing project that has produced important new results and publications in 1997.

溶剂质子纵向（自旋晶格）弛豫时间 顺磁造影剂的 (1/T1M) 与 医学磁共振成像 (MRI) 中的图像对比度。 有 质子弛豫的两个贡献者，称为内球体和外球体 领域。 所罗门和布隆伯根证明了内球体 质子纵向弛豫时间取决于三个因素， 即旋转相关时间（R），电子 自旋晶格弛豫时间（S）和水的寿命 顺磁性金属位点 (M) 中的质子。 外层弛豫 已发现取决于溶质的相关时间和 溶剂扩散开 ( ) 并再次扩散电子自旋晶格 放松时间。 然而，直接测量这些组件 并不容易获得。 核磁弛豫色散 （NMRD）只能提供对上述参数的估计。 在这项研究中，我们报告了电子的成功应用 顺磁共振（EPR），使用氧钒络合到两种不同的 螯合物（EDTA 和 DTPA）作为自旋探针，直接测量 旋转相关时间。 此外，估计来自 拟合核磁弛豫色散 (NMRD) 曲线 验证所获得的 EPR 结果。 这是一个正在进行的项目 1997 年取得了重要的新成果和出版物。