ENTERAL GLUTAMINE AND PRESERVATION OF BODY PROTEIN

肠内谷氨酰胺和身体蛋白质的保存

• 批准号: 6278671
• 负责人: DOMINQUE DARMAUN
• 金额: $ 2.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278671
• 关键词: clinical research; glucocorticoids; glutamine; hormone regulation /control mechanism; human subject; parenteral feedings; protein metabolism; secretion; somatotropin; tube feeding

The overall purpose of these studies is to test the hypothesis that glutamine has a protein anabolic effect in humans. Although Glutamine is the most abundant amino acid in the body, and can be synthesized de novo, muscle free glutamine pool can be depleted with stress and protein wasting diseases, and replenishment of the glutamine stores is associated with improved nitrogen balance in such conditions. These studies will use infusion of stable and radioactive tracers of leucine and glutamine to determine in vivo in healthy humans: 1) whether glutamine stimulates growth hormone secretion; 2) whether an acute decrease in plasma glutamin concentration has a protein catabolic effect; 3) whether enteral glutamine can alter the catabolic response to glucocorticoids; and 4) whether an acute decrease in plasma glutamine concentration enhances the protein catabolic response to glucocorticoids. These studies will expand understanding of the physiologic role of glutamine in protein metabolism and should, if they provide evidence for an anabolic role of glutamine in humans, support the use of enteral or parenteral supplementation as an ineffective, inexpensive means of preserving body protein stores during severe illness.

这些研究的总体目的是检验以下假设。 谷氨酰胺在人类中具有蛋白质合成代谢作用。 虽然谷氨酰胺 是体内最丰富的氨基酸，可以合成DE Novo，无肌肉谷氨酰胺池可以用压力和蛋白质耗尽 浪费疾病，谷氨酰胺商店的补充是 在这种情况下，与改善氮平衡有关。 这些 研究将使用亮氨酸稳定和放射性示踪剂的输注 和谷氨酰胺确定健康人体内的体内：1）是否是否 谷氨酰胺刺激生长激素分泌； 2）是否急性 血浆谷氨酰胺浓度的降低具有蛋白质分解代谢 影响; 3）肠内谷氨酰胺是否可以改变分解代谢反应 糖皮质激素； 4）血浆谷氨酰胺是否急性减少 浓度增强了蛋白质分解代谢反应 糖皮质激素。 这些研究将扩大对 谷氨酰胺在蛋白质代谢中的生理作用，如果它们应 提供谷氨酰胺在人类中的合成代谢作用的证据，支持 使用肠内或肠胃外补充作为无效的使用， 在严重期间保存身体蛋白质储存的廉价手段 疾病。