AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

血管硬度特性与年龄相关的变化

• 批准号: 6097803
• 负责人: Edward G Lakatta
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6097803
• 关键词: adult human (21+); aerobic exercise; aging; angiocardioultrasonography; arteriosclerosis; blood pressure; body composition; cardiovascular disorder epidemiology; carotid artery; clinical research; hormone therapy; human subject; myocardium; pulse pressure wave; sex hormones; somatotropin; vascular resistance

SUMMARY OF WORK The ultimate goals of this project are to determine how arterial stiffness properties influence myocardial structure and function and contribute to cardiovascular morbidity and mortality. A. We have examined the contribution of arterial stiffness to left ventricular (LV) mass in 695 men and 616 women from Taiwan (Contract #N01-AG-02-2118). In both sexes, the major predictors of LV mass were systolic blood pressure, body surface area and age; AGI contributed minimally (r2 less than or equal to 0.006) to LV mass in either sex. B. To determine whether growth hormone or sex steroid supplementation ameliorates arterial stiffness properties in older adults with deficiencies of these substances, we are measuring pulse wave velocity and AGI in men and women aged 65 years and older, before and after hormonal replacement. C. We are testing the hypothesis that 1-2 years of home-based aerobic exercise training can reduce arterial stiffness in the multicenter NIH-sponsored Activities Counseling Trial of 810 subjects 35-75 years old. D. To determine whether aerobic exercise training can reduce the elevated arterial stiffness of older heart failure patients and whether such changes in arterial stiffness are related to training-induced improvement of aerobic performance, we will measure arterial stiffness and peak VO2 before and after a 3 month program of aerobic training. E. A multicenter study to determine whether arterial stiffness is an independent risk factor for cardiovascular events in elderly free-living persons has been initiated in collaboration with the Epidemiology Demography Biometry Program of the intramural NIA. F. Follow-up measurements of arterial stiffness on endurance trained older men and their sedentary age peers, initially studied in 1989-1991 have been obtained to determine whether chronic endurance training attenuates the normal age-associated increase in arterial stiffness. G. Arterial stiffness will be measured in the Pittsburgh, PA site for the Cardiovascular Health Study, a comprehensive characterization of cardiovascular structure and function in community dwelling clinically healthy men and women greater than or equal to 65 years old. Long-term follow-up of this cohort will allow us to examine the prognostic significance of arterial stiffness in an older population. H. The relationship between arterial stiffness and some newly discovered hormones involved in sodium and blood pressure regulation (plasma ouabain-like factor and marinobufagenin) is being examined in BLSA subjects across a large age and blood pressure range. I. We have developed a novel index of arterial function, the Decay Index, defined from the exponential rate of decline in the Doppler internal carotid artery flow rate from peak systole to end-diastole.

工作总结 本次会议的最终目标 项目是确定动脉僵硬度特性如何影响 心肌的结构和功能对心血管有贡献 发病率和死亡率。 A. 我们审查了以下方面的贡献： 695 名男性和 616 名男性的动脉僵硬度与左心室 (LV) 质量的关系 来自台湾的女性（合同#N01-AG-02-2118）。在两性中， 左心室质量的主要预测因素是收缩压、身体 表面积和年龄； AGI 贡献最小（r2 小于或 等于 0.006) 至任一性别的 LV 质量。 B、判断是否 生长激素或性类固醇补充剂可改善动脉状况 缺乏这些功能的老年人的僵硬特性 物质，我们正在测量男性的脉搏波速度和 AGI 以及 65 岁及以上的女性，在激素治疗前后 替代品。 C. 我们正在检验以下假设：1-2 年 家庭有氧运动训练可以减少动脉硬化 NIH 赞助的 810 多中心活动咨询试验 受试者年龄35-75岁。 D.判断是否进行有氧运动 训练可以减少老年人心脏升高的动脉僵硬度 衰竭患者以及动脉僵硬度的这种变化是否是 与训练引起的有氧运动能力的提高有关， 我们将在 3 之前和之后测量动脉僵硬度和峰值摄氧量 月有氧训练计划。 E. 一项多中心研究 确定动脉硬化是否是一个独立的危险因素 自由生活老年人的心血管事件 与流行病学人口统计学合作发起 壁内 NIA 的生物测定计划。 F. 后续行动 测量经过耐力训练的老年男性的动脉硬度 以及他们在 1989-1991 年间进行的久坐年龄同龄人的初步研究 已获得确定是否进行长期耐力训练 减弱与年龄相关的动脉僵硬度的正常增加。 G. 动脉僵硬度将在宾夕法尼亚州匹兹堡进行测量 心血管健康研究，全面表征 社区住宅心血管结构和功能的研究 年龄大于或等于 65 岁的临床健康男性和女性 老的。对该队列的长期随访将使我们能够检查 老年人动脉硬化的预后意义 人口。 H. 动脉僵硬度与一些因素之间的关系 新发现的与钠和血压有关的激素 调节（血浆哇巴因样因子和海蟾蜍配基）是 在大年龄和血液的 BLSA 受试者中接受检查 压力范围。 I. 我们开发了一种新颖的动脉指数 函数，衰减指数，由指数率定义 多普勒颈内动脉流速从峰值下降 收缩期至舒张末期。