Air Pollution Impacts on Cardiopulmonary Disease in Beijing: An integrated study of Exposure Science, Toxicogenomics and Environmental Epidemiology

北京空气污染对心肺疾病的影响：暴露科学、毒理基因组学和环境流行病学的综合研究

• 批准号: NE/N007182/1
• 负责人: Miranda Loh
• 金额: $ 63.09万
• 依托单位: Institute of Occupational Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FN007182%2F1
• 关键词: Air; Pollution; Impacts; Cardiopulmonary; Disease

This proposal aims to do a comprehensive evaluation of air pollution health impacts on cardiopulmonary health through integration of exposure, epidemiology, and toxicology/toxicogenomic studies. We will do detailed assessments of people's exposure to air pollution, estimating exposures for long- and short-term epidemiological analyses, and linking these to epidemiological analyses of long term health impacts based on a cohort study, short-term effects (i.e. biomarkers, blood pressure, heart rhythm, peak flow) based on a panel study, and early life effects based on a birth cohort. Additionally, we test the effect of reducing exposure to fine particles, but not gases, by designing an intervention study where volunteers will wear a face mask and examining the exposure-response relationship for the same short-term effects we evaluate in the panel study. The short-term physiological measurements we conduct in the epidemiological studies will provide insight into the mechanisms by which air pollutions affects cardiopulmonary health. To complement the human based studies into mechanisms of action, our project will also conduct extensive in vivo analyses of mechanistic effects, and early life toxicogenomics/metabonomics. Finally, we will provide practical advice to stakeholders based on our study findings, by assessing the potential value of selected strategies for control of exposure to outdoor health protection in a health risk assessment.

该建议旨在通过整合暴露，流行病学和毒理学/毒理学研究，对空气污染健康对心肺健康的影响进行全面评估。我们将对人们暴露于空气污染的暴露，估算长期和短期流行病学分析的暴露，并将其与长期健康影响的流行病学分析联系起来，该分析基于队列研究，短期研究，基于平板研究和早期的生命效应，基于panel and cot效应。此外，我们通过设计一项干预研究来测试减少对细颗粒（而不是气体）的影响，在该研究中，志愿者将戴上口罩并检查我们在面板研究中评估的相同短期效应的暴露响应关系。我们在流行病学研究中进行的短期生理测量将提供有关空气污染影响心肺健康的机制的洞察力。为了补充人类对作用机制的研究，我们的项目还将在体内进行大量的机械作用分析以及早期生命毒理学组学/替代学。最后，我们将根据我们的研究结果为利益相关者提供实用建议，并通过评估选择在健康风险评估中控制户外健康保护的选定策略的潜在价值。

项目成果

Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos.

• DOI: 10.1080/17435390.2018.1461267
• 发表时间: 2018-06
• 期刊: Nanotoxicology
• 影响因子: 5
• 作者: Duan J;Liang S;Yu Y;Li Y;Wang L;Wu Z;Chen Y;Miller MR;Sun Z
• 通讯作者: Sun Z

Street-scale air quality modelling for Beijing during a winter 2016 measurement campaign

• DOI: 10.5194/acp-2019-783
• 发表时间: 2019-09
• 期刊: Atmospheric Chemistry and Physics
• 影响因子: 6.3
• 作者: M. Biggart;J. Stocker;R. Doherty;O. Wild;M. Hollaway;Davis Carruthers;Jie Li;Qiang Zhang

In-mask temperature and humidity can validate respirator wear-time and indicate lung health status.

• DOI: 10.1038/s41370-018-0089-y
• 发表时间: 2019-06
• 期刊: Journal of exposure science & environmental epidemiology
• 影响因子: 4.5
• 作者: Cherrie JW;Wang S;Mueller W;Wendelboe-Nelson C;Loh M
• 通讯作者: Loh M