PREMENOPAUSAL RISK FACTORS FOR CORONARY HEART DISEASE IN BLACK & WHITE WOMEN

黑人绝经前冠心病的危险因素

• 批准号: 6116123
• 负责人: Glenn S Gerhard
• 金额: $ 11.58万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116123
• 关键词: Chordata; epidemiology; nutrition; nutrition related tag

Premenopausal black women have a 2- to 3-fold greater rate of coronary heart disease (CHD) than premenopausal white women. The purpose of this study was to provide greater insight into the reasons for this difference, which are currently unclear. We compared CHD risk factors in 99 black and 100 white, healthy, premenopausal women, aged 18 to 45 years, and of relatively advantaged socioeconomic status. Compared with white women, black women had a higher body mass index (32.0 _ 9.2 vs 29.0 _ 9.4 kg/m2, p=0.021), and higher systolic (124 _17 vs 115 _ 14 mm Hg, p<0.0001) and diastolic (79 _ 14 vs 75 _ 11 mm Hg, p=0.048) blood pressures. The mean plasma lipoprotein(a) concentration was markedly higher in the black women (40.2 _ 31.3 mg/dl) than in the white women (19.2 _ 23.7 mg/dl, p<0.0001). The plasma total homocysteine level was also higher in the black women (8.80 _ 3.38 vs 7.81 _ 2.58 umol/L, p=0.013). The black women, however, had lower plasma triglyceride levels (0.91 _ 0.46 vs 1.22 _ 0.60 mmol/L, p<0.0001), and a trend toward higher high-density lipoprotein (HDL) cholesterol levels (1.37 _ 0.34 vs 1.29 _ 0.31 mmol/L, p=0.064) than the white women. Plasma total and low-density lipoprotein (LDL) cholesterol levels were similar, despite a greater consumption of saturated fat and cholesterol by the black women. Rates of cigarette smoking and alcohol intake were low and similar between the races. Premenopausal black women had a higher mean body mass index, blood pressure, lipoprotein(a), and plasma total homocysteine level, and a greater consumption of saturated fat and cholesterol than white women. These differences in coronary risk factors may place the black women in our study at increased risk for CHD compared with the white women. FUNDING Collaboration with Dr. Gerhard at OHSU PUBLICATIONS Gerhard GT, Sexton G, Malinow MR, Wander RC, Connor SL, Pappu AS, Connor WE. Premenopausal black women have more risk factors for coronary heart disease than white women. Am J Cardiol 82:1040-1045, 1998.

绝经前黑人女性的罹患率要高出 2 至 3 倍 冠心病（CHD）的发病率高于绝经前白人女性。 这 这项研究的目的是为了更深入地了解原因 对于这种差异，目前尚不清楚。 我们比较了冠心病 99 名黑人和 100 名白人健康绝经前妇女的危险因素， 年龄在18岁至45岁之间，具有相对优越的社会经济地位 地位。 与白人女性相比，黑人女性的体重更高 指数（32.0 _ 9.2 vs 29.0 _ 9.4 kg/m2，p=0.021）和更高的收缩压 (124 _17 vs 115 _ 14 mm Hg, p<0.0001) 和舒张压 (79 _ 14 vs 75 _ 11 毫米汞柱，p=0.048) 血压。 平均血浆脂蛋白(a) 黑人女性的浓度明显更高 (40.2 _ 31.3 mg/dl）高于白人女性（19.2 _ 23.7 mg/dl，p<0.0001）。 这 黑人女性的血浆总同型半胱氨酸水平也较高 （8.80 _ 3.38 与 7.81 _ 2.58 umol/L，p=0.013）。 黑人妇女们， 然而，血浆甘油三酯水平较低（0.91 _ 0.46 vs 1.22 _ 0.60 mmol/L，p<0.0001)，并且有更高高密度的趋势 脂蛋白 (HDL) 胆固醇水平（1.37 _ 0.34 与 1.29 _ 0.31 mmol/L，p=0.064）高于白人女性。 血浆总密度和低密度 脂蛋白（LDL）胆固醇水平相似，尽管更高 黑人女性消耗饱和脂肪和胆固醇。 吸烟率和饮酒率较低且相似 种族之间。 绝经前黑人女性的平均身材较高 质量指数、血压、脂蛋白(a) 和血浆总量 同型半胱氨酸水平，以及更多的饱和脂肪和 胆固醇含量高于白人女性。 冠状动脉风险的这些差异 因素可能会使我们研究中的黑人女性面临更高的风险 CHD 与白人女性相比。 与博士的资助合作 OHSU 出版物的格哈德 Gerhard GT、Sexton G、Malinow MR、Wander RC，康纳 SL，帕普 AS，康纳 WE。 绝经前的黑人女性有 冠心病的危险因素比白人女性更多。 杰姆 心脏 82：1040-1045，1998。