CORONARY HEART DISEASE INCIDENCE IN RELATION TO TOTAL HOMOCYSTEINE

冠心病发病率与总同型半胱氨酸的关系

• 批准号: 6116121
• 负责人: AARON R FOLSOM
• 金额: $ 11.58万
• 依托单位: OREGON REGIONAL PRIMATE RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-15 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116121
• 关键词: Chordata; epidemiology; nutrition; nutrition related tag

We used a prospective case-cohort design to determine whether total homocysteine (tHcy)-related factors are associated with incidence of coronary heart disease (CHD) over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women. Age-, race-, and field center-adjusted CHD incidence was associated positively (P<0.05) with tHcy in women but not men, and CHD was associated negatively (P<0.05) with plasma folate (women only), plasma pyridoxal 5=-phosphate (both sexes), and vitamin supplementation (women only). However, after accounting for other risk factors, only plasma pyridoxal 5=-phosphate was associated with CHD incidence; the relative risk for the highest versus lowest quintile of pyridoxal 5=-phosphate was 0.28 (95% CI=0.1 to 0.7). There was no association of CHD with the C677 T mutation of the methylenetetrahydrofolate reductase gene or with three mutations of the cystathionine ?-synthase gene. Our prospective findings add uncertainty to conclusions derived mostly from cross-sectional studies that tHcy is a major, independent, causative risk factor for CHD. Our findings point more strongly to the possibility that vitamin B6 offers independent protection. Randomized trials, some of which are under way, are needed to better clarify the interrelationships of tHcy, B vitamins, and cardiovascular disease. FUNDING Collaboration with Dr. Aaron Folsom, University of Minnesota PUBLICATIONS Folsom AR, Nieto FJ, McGovern PG, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, Hess DL, Davis CE. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins The Atherosclerosis Risk in Communities (ARIC) Study. Circulation 98:204-210, 1998.

我们使用了潜在的案例 - 霍特设计来确定是否是否 总同型半胱氨酸（THCY）相关因素与 冠心病（CHD）的发病率平均3.3年 在中年男女的混血儿样本中的随访。 年龄-， 种族和野外调整后的冠心病发病率相关 在女性而不是男人的情况下，阳性（p <0.05），而不是男人，而冠心病是 与血浆叶酸（仅女性），血浆相关（p <0.05）（p <0.05） 吡ido醇5 = - 磷酸盐（性别）和补充维生素 （仅女性）。 但是，在考虑了其他风险因素之后，仅 血浆吡啶还毒5 = - 磷酸与CHD发病率有关；这 吡啶毒素的最高五分五五分之一的相对风险 5 = - 磷酸盐为0.28（95％CI = 0.1至0.7）。 没有关联 与甲基四氢叶酸的C677 T突变的CHD 还原酶基因或胱淀粉的三个突变？ - 联合酶 基因。 我们的前瞻性发现增加了得出的结论的不确定性 大多数来自横断面研究，Thcy是一项主要，独立的， CHD的病因危险因素。 我们的发现更强烈地指向 维生素B6提供独立保护的可能性。 需要进行随机试验，其中一些正在进行中以改善 阐明THCY，B族维生素和心血管的相互关系 疾病。 资助与大学的Aaron Folsom博士合作 明尼苏达州出版物Folsom AR，Nieto FJ，McGovern PG，McGovern PG， Tsai My，Malinow先生，Eckfeldt JH，Hess DL，Davis CE。 预期 研究冠心病的发病率与禁食总数 同型半胱氨酸，相关的遗传多态性和B族维生素 社区（ARIC）研究中的动脉粥样硬化风险。 循环 98：204-210，1998。