CORTICAL SURFACE AREA & THICKNESS IN HEALTH AND DISEASE

皮质表面积

• 批准号: 6024688
• 负责人: PATRICK E BARTA
• 金额: $ 36.14万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6024688
• 关键词: Downs syndrome; bipolar depression; cerebral cortex; clinical research; human subject; method development; neuroanatomy; neurobiology; schizophrenia; Downs syndrome; bipolar depression; cerebral cortex; clinical research; human subject; method development; neuroanatomy; neurobiology; schizophrenia

We propose to explore the neurobiological basis of Down syndrome, schizophrenia, and bipolar disorders using novel methods for measuring cortical neuroanatomy. We will develop and validate methods for measuring surface area, thickness, and thickness distribution of cortical structures, and use these methods in four subject groups: healthy individuals, and patients with Down syndrome, schizophrenia and bipolar disorder. We hypothesize that surface area and thickness measures will be more informative that conventional volume measures, and that patients with Down syndrome will have global cortical deficits. We believe that specific cortical regions will be affected in schizophrenia (heteromodal cortex) and bipolar disorder (entorhinal cortex). Although we focus here on three diseases, we believe that the methods that we will develop would be useful to researchers studying other diseases too. We plan to make our soDware (written in the JAVA language and thus portable to most popular computers including C's, Mac's and Unix-based systems) available on the laboratory's web site.

我们建议探索唐氏综合症的神经生物学基础， 精神分裂症和双相情感障碍使用新型方法测量皮质 神经解剖学。我们将开发和验证测量表面积的方法， 皮质结构的厚度和厚度分布，并使用这些 四个主题组的方法：健康个体，患者 综合征，精神分裂症和躁郁症。我们假设表面积 厚度措施将更具信息性 措施，唐氏综合症患者将具有全球皮质 缺陷。我们认为，特定的皮质区域将受到影响 精神分裂症（异源性皮层）和躁郁症（内嗅皮层）。 尽管我们在这里专注于三种疾病，但我们相信我们的方法 会发展对研究其他疾病的研究人员也很有用。我们 计划制作我们的Sodware（用Java语言编写，因此可移植 最受欢迎的计算机，包括C，Mac和UNIX的系统）可用 在实验室的网站上。