COMMUNITY BASED STUDY ON OCCUPATIONAL ASTHMA, ECRHS-OA

职业性哮喘社区研究，ECRHS-OA

• 批准号: 6184890
• 负责人: MANOLIS KOGEVINAS
• 金额: $ 4.56万
• 依托单位: MUNICIPAL INSTITUTE OF MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6184890
• 关键词: Australia; British Isles; Europe; France; Germany; Italy; Scandinavian country; United States; asthma; atopy; blood chemistry; bronchus disorder; clinical research; diet; disease /disorder proneness /risk; dosage; dust; health care service utilization; human population study; human subject; immunoglobulin E; industry; interview; longitudinal human study; lung; nutrition related tag; occupational health /safety; occupations; questionnaires; respiratory disorder epidemiology; respiratory function; spirometry; tobacco abuse; work site; young adult human (21-34); Australia; British Isles; Europe; France; Germany; Italy; Scandinavian country; United States; asthma; atopy; blood chemistry; bronchus disorder; clinical research; diet; disease /disorder proneness /risk; dosage; dust; health care service utilization; human population study; human subject; immunoglobulin E; industry; interview; longitudinal human study; lung; nutrition related tag; occupational health /safety; occupations; questionnaires; respiratory disorder epidemiology; respiratory function; spirometry; tobacco abuse; work site; young adult human (21-34)

The overall aim of this large multicentre community based study of young men and women is to examine the occupations, industries and exposures in the work-place which are associated with a high risk for asthma and other adverse respiratory health effects, with particular emphasis on specific exposures of predominantly female occupations (irritants, detergents and other asthmagens), and of other high risk major occupations which have not been adequately examined. The main hypotheses of the study are that respiratory diseases are strongly related with exposure in the workplace, that a considerable proportion of adult onset asthma is associated with these exposures and that the importance of occupational risk factors for asthma has been underestimated, particularly among women. The occupational asthma study (ECRHS- OA) forms part of a wider international multicentre survey on respiratory health (European Community Respiratory Health Survey- ECRHS). The first phase of the ECRHS was conducted in 1991/92 and examined risk factors for asthma and atopy in subjects aged 20-44 years. The study is currently updated (ECRHS-II) following-up approximately 17,000 young adults from 12 countries (Australia, Belgium, France, Germany, Iceland, Italy, Norway, Spain, Sweden, Switzerland, UK and USA). Those subjects who took part in the first survey will be re-contacted in 1999, to determine risk factors for incidence and remission of asthma, other respiratory symptoms, atopy, changes in bronchial responsiveness and lung function. Subjects will be asked to perform a forced spirometry, methacholine challenge and to provide blood samples for IgE testing. A questionnaire administrated by trained interviewers will be delivered requesting information on respiratory symptoms and diseases, socio-demographic factors, tobacco smoking, complete occupational history since the last survey, environmental exposures, family history, diet, treatment and use of health services. Modular occupational questionnaires will be developed for subjects employed as cleaners, homemakers, welders, metal workers, nurses, and subjects exposed to organic dusts in the paper and textile industries. The study will provide valid and precise estimates on the importance of specific occupations, industries and exposures in relation to asthma incidence and prevalence, similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function.

这项基于多中心社区的年轻男女研究的总体目的是检查工作场所的职业，行业和暴露，这些职业与哮喘和其他不良呼吸健康影响的高风险有关，并特别强调特定的特定暴露于主要的女性职业（刺激性，洗涤剂，洗涤剂和其他asthmagens and Adece）和其他高级职业的影响。 该研究的主要假设是，呼吸道疾病与工作场所的暴露密切相关，很大一部分成人哮喘与这些暴露有关，并且在女性中尤其是妇女中低估了哮喘的职业危险因素的重要性。 职业哮喘研究（ECRHS-OA）构成了更广泛的国际呼吸健康多中心调查的一部分（欧洲共同体呼吸健康调查 - ECRHS）。 ECRHS的第一阶段于1991/92年进行，并检查了20-44岁患者哮喘和特应性的危险因素。 该研究目前已更新（ECRHS-II），跟踪来自12个国家（澳大利亚，比利时，法国，德国，冰岛，意大利，挪威，西班牙，瑞典，瑞士，瑞士，英国和美国）的约17,000名年轻人。 参加第一次调查的受试者将在1999年重新接触，以确定哮喘发病率和缓解哮喘，其他呼吸道症状，特应性，支气管反应性变化和肺功能的风险因素。 将要求受试者执行强制肺活量测定法，甲基苯胺挑战，并为IgE测试提供血液样本。 一份由训练有素的访调员管理的问卷将提供有关呼吸症状和疾病，社会人口统计学因素，烟草吸烟，完整的职业历史的信息，自上次调查，环境暴露，家族史，饮食，饮食，治疗和健康服务的使用以来。 将针对用作清洁工，家庭主妇，焊工，金属工人，护士以及暴露于纸张和纺织工业中有机粉尘的受试者的受试者开发模块化的职业问卷。 该研究将提供有关特定职业，行业和暴露于哮喘发病率和患病率的特定职业，行业和暴露率的重要估计，对其他呼吸道症状和疾病的相似估计以及肺功能下降的相似估计。