ELECTROMECHANICAL PROPERTIES OF INTERVERTEBRAL DISC

椎间盘的机电特性

• 批准号: 6345803
• 负责人: Weiyong Gu
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6345803
• 关键词: backache; biomechanics; body water dehydration; bone density; collagen; diagnosis design /evaluation; disease /disorder etiology; electrical conductance; electrochemistry; electrodes; intervertebral disk; mechanical pressure; musculoskeletal disorder diagnosis; proteoglycan; spine disorder; statistics /biometry; swine

Low-back pain is a major socio-economic concern in this country. Although the exact cause for low back pain is unclear, the degenerative changes of the intervertebral disc (IVD), a crucial component of the human spine, have been implicated as a possible primary etiologic factor. The long-term objectives of this project are: (1) to better understand the biomechanics of the IVD, (2) to delineate the biomechanical etiology of disc failure, (3) to elucidate the pathophysiology of low-back pain, and (4) to develop new, minimally invasive diagnostic tools for disc degeneration. The purpose of this pilot research is to develop new techniques and experimental protocols for the investigation of relations of material properties to tissue composition and structure. The specific aims are to (1) investigate effects of proteoglycan (PG) content and collagen matrix density on tissue hydration, (2) investigate electrical properties of normal and PG-extracted IVD tissues, and (3) investigate dynamic compressive behavior of normal and PG-extracted IVD tissues. Three experimental studies will be developed and performed in this project. They are: (1) measurements of water content and true density of solid matrix, (2) measurement of electrical conductivity, and (3) dynamic compression testing of normal and PG-extracted animal IVD tissues. The experimental data will also be analyzed using a mechano-electrochemical theory to elucidate the relations of material properties to tissue composition and structure. These studies will help to understand the mechanism for regulating tissue hydration, the effect of disc degeneration on material properties and biomechanical behavior, and the biomechanical etiology of disc failure in human IVDs. The results will be useful for the future development of theoretical modeling as well as minimally invasive diagnostic tools for disc degeneration.

低背痛是该国的主要社会经济关注点。尽管尚不清楚腰痛的确切原因，但椎间盘（IVD）的退化性变化（人脊柱的关键成分）已被视为可能的主要病因学因子。 该项目的长期目标是：（1）更好地了解IVD的生物力学，（2）描绘椎间盘衰竭的生物力学病因，（3）阐明低背疼痛的病理生理学，（4）开发新的，微型侵入性的侵入性诊断工具，用于椎间盘变性。 该试点研究的目的是开发新技术和实验方案，以研究材料特性与组织组成和结构的关系。 具体目的是（1）研究蛋白聚糖（PG）含量和胶原蛋白基质密度对组织水合的影响，（2）研究正常和PG提取的IVD组织的电性能，以及（3）研究正常和PG提取的IVD组织的动态压缩行为。该项目将开发和执行三项实验研究。 它们是：（1）测量水含量和固体基质的真实密度，（2）电导率的测量以及（3）对正常和PG提取的动物IVD组织的动态压缩测试。 还将使用机械电化学理论分析实验数据，以阐明材料特性与组织组成和结构的关系。 这些研究将有助于了解调节组织水合的机制，椎间盘退化对材料特性和生物力学行为的影响以及人类IVD中椎间盘衰竭的生物力学病因。 该结果将对理论建模的未来开发以及椎间盘退化的最低侵入性诊断工具有用。