Design of adhesive nanomaterials for tissue repair

用于组织修复的粘合纳米材料的设计

• 批准号: MR/X033546/1
• 负责人: Maria Chiara Arno
• 金额: $ 148.02万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX033546%2F1
• 关键词: Design; adhesive; nanomaterials; tissue; repair

Globally, 310 million major surgeries are performed each year, with the number continuing to grow. Current surgical closure methods involve the use of invasive techniques such as sutures or staples, which often result in secondary tissue damage and microbial infection. To address these shortcomings, biological adhesives have emerged as an effective wound sealing solution, currently constituting a market share of $38 billion. Nanotechnology has emerged as a new tool for the design of adhesive biomaterials. Recent advances have shown that silica nanoparticles are able to glue biological tissue together by forming an adhesive layer through adsorption of proteins onto their surfaces. While this approach provides a fundamental proof of concept, nanoparticle glues are so far limited to inorganic materials, the properties (shape, size, and functionality) of which are difficult to control. In contrast, organic nanoparticles can be readily manipulated to achieve a wider range of surface functionality, morphologies, and dimensions, and hence are anticipated to enable major advances in tissue adhesive applications through the ability to tune and tailor their adhesive properties.My vision is to develop new organic nanomaterials that will provide a much richer and versatile platform for tuning the adhesive strength to tissues, enabling a step change in the field. This research will deliver important fundamental understanding of the structure-activity relationship between nanoparticle properties and adhesive behaviour and in doing so it will fully realise the potential of nanostructures as tissue adhesives.

全球每年进行3.1亿例大手术，并且这一数字还在持续增长。目前的手术闭合方法涉及使用缝合或钉书钉等侵入性技术，这通常会导致继发性组织损伤和微生物感染。为了解决这些缺点，生物粘合剂已成为一种有效的伤口密封解决方案，目前市场份额为 380 亿美元。纳米技术已成为设计粘合生物材料的新工具。最近的进展表明，二氧化硅纳米粒子能够通过将蛋白质吸附到生物组织表面形成粘合层，将生物组织粘合在一起。虽然这种方法提供了基本的概念证明，但纳米颗粒胶迄今为止仅限于无机材料，其特性（形状、尺寸和功能）难以控制。相比之下，有机纳米颗粒可以很容易地进行操纵，以实现更广泛的表面功能、形态和尺寸，因此预计通过调整和定制其粘合性能的能力，将在组织粘合应用方面取得重大进展。我的愿景是开发新的有机纳米材料，这将为调整组织的粘合强度提供更丰富和多功能的平台，从而实现该领域的重大变革。这项研究将为纳米颗粒特性和粘合行为之间的结构-活性关系提供重要的基础理解，从而充分实现纳米结构作为组织粘合剂的潜力。