NEURAL CONTROL OF THE JAW UNDER PAIN

疼痛下颌的神经控制

• 批准号: 6176956
• 负责人: NORMAN CAPRA
• 金额: $ 24.81万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176956
• 关键词: Macaca mulatta; biological signal transduction; brain mapping; brain stem; disease /disorder model; electromyography; histology; immunocytochemistry; jaw; jaw movement; motor cortex; muscle function; neural information processing; neuromuscular system; oral facial pain; sensorimotor system; temporomandibular joint syndrome

DESCRIPTION (Adapted from the investigator's Abstract): The goal of the proposal is to understand how muscle pain associated with temporomandibular disorders (TMD) affects neuromotor performance in primates. Current evidence suggests that at least some myogenous jaw pain in humans causes a protective adaptation response, in which there is decreased activity in agonist muscles, and increased activity in antagonist muscles, resulting in restricted ranges of jaw motion. Currently, a hypothetical brainstem model has been proposed to explain this, but it is equally possible that higher levels of motor control are involved, such as the motor cortex, in addition to, or instead of, the brainstem. Though conscious responses to pain, and control of jaw muscle contraction both involve the sensorimotor cortex, the region's potential contribution to the protective adaptation response has not been studied. Since the applicants have developed a suitable animal model for producing transient jaw muscle pain in the awake monkey (Macaca mulatta) and for observing its effects on voluntary jaw motion and jaw position, the first aim therefore is to carry out a parametric analysis of normal jaw motion and muscle activity during stereotyped motor tasks and automatic chewing, and to repeat the experiment in the presence of induced muscle pain. The second aim is to define relationships between the types and locations of corticomotoneuronal activity, and the same peripheral variables associated with these acts in normal animals. The third aim is to repeat this study of the motor cortex in the presence of induced muscle pain. The applicant hypothesizes that cortical neurons provide signals correlated with the initiation and execution of jaw movements and the maintenance of jaw positions, and that the signals change during the conscious pain experience in such a way as alter muscle contraction patterns, and subsequent jaw motion. They consider that their preliminary data support this proposition. The alternative hypothesis proposed is that this change in cortical signalling does not occur, in which case the applicant will conclude that the pain-adaptation response is due primarily to brainstem mechanisms. The applicant believes the study is significant because it can provide a better understanding of cortical influences in the control of jaw movement generally, and in particular, define the cortex's role in human motor responses to jaw muscle pain.

描述（改编自研究者的摘要）： 建议是了解肌肉疼痛与颞下颌关节紊乱有何关联 疾病（TMD）影响灵长类动物的神经运动表现。 当前的 有证据表明，至少人类的某些肌源性下颌疼痛会导致 保护性适应反应，其中活动减少 主动肌的活动增加，拮抗肌的活动增加，从而导致 下颌运动范围受限。 目前，假设的脑干模型 有人建议对此进行解释，但同样有可能更高 涉及运动控制水平，例如运动皮层，此外 到或代替脑干。 尽管对疼痛有意识的反应，并且 下颌肌肉收缩的控制都涉及感觉运动皮层 该地区对保护性适应反应的潜在贡献 没有被研究过。 由于申请人已经开发出合适的动物 在清醒猴子（Macaca）中产生短暂下巴肌肉疼痛的模型 mulatta）并观察其对下颌自主运动和下颌的影响 因此，首要目标是进行参数分析 在刻板运动任务期间正常的下巴运动和肌肉活动以及 自动咀嚼，并在存在诱导的情况下重复实验 肌肉疼痛。 第二个目标是定义类型之间的关系 和皮质运动神经元活动的位置，以及相同的外周 与正常动物的这些行为相关的变量。 第三个目标是 在存在诱导肌肉的情况下重复运动皮层的这项研究 疼痛。 申请人假设皮质神经元提供信号 与下颌运动的启动和执行相关 维持下巴位置，并且信号在 有意识的疼痛体验会改变肌肉收缩 模式，以及随后的下巴运动。 他们认为他们的初步 数据支持这一主张。 提出的替代假设是 皮质信号传导不会发生这种变化，在这种情况下 申请人将得出结论，疼痛适应反应主要是由于 脑干机制。 申请人认为该研究具有重要意义 因为它可以更好地理解大脑皮层的影响 总体上控制下巴运动，特别是定义皮质的 在人类对下颌肌肉疼痛的运动反应中的作用。