NEURAL CONTROL OF THE JAW UNDER PAIN

疼痛下颌的神经控制

• 批准号: 6176956
• 负责人: NORMAN CAPRA
• 金额: $ 24.81万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176956
• 关键词: Macaca mulatta; biological signal transduction; brain mapping; brain stem; disease /disorder model; electromyography; histology; immunocytochemistry; jaw; jaw movement; motor cortex; muscle function; neural information processing; neuromuscular system; oral facial pain; sensorimotor system; temporomandibular joint syndrome; Macaca mulatta; biological signal transduction; brain mapping; brain stem; disease /disorder model; electromyography; histology; immunocytochemistry; jaw; jaw movement; motor cortex; muscle function; neural information processing; neuromuscular system; oral facial pain; sensorimotor system; temporomandibular joint syndrome

DESCRIPTION (Adapted from the investigator's Abstract): The goal of the proposal is to understand how muscle pain associated with temporomandibular disorders (TMD) affects neuromotor performance in primates. Current evidence suggests that at least some myogenous jaw pain in humans causes a protective adaptation response, in which there is decreased activity in agonist muscles, and increased activity in antagonist muscles, resulting in restricted ranges of jaw motion. Currently, a hypothetical brainstem model has been proposed to explain this, but it is equally possible that higher levels of motor control are involved, such as the motor cortex, in addition to, or instead of, the brainstem. Though conscious responses to pain, and control of jaw muscle contraction both involve the sensorimotor cortex, the region's potential contribution to the protective adaptation response has not been studied. Since the applicants have developed a suitable animal model for producing transient jaw muscle pain in the awake monkey (Macaca mulatta) and for observing its effects on voluntary jaw motion and jaw position, the first aim therefore is to carry out a parametric analysis of normal jaw motion and muscle activity during stereotyped motor tasks and automatic chewing, and to repeat the experiment in the presence of induced muscle pain. The second aim is to define relationships between the types and locations of corticomotoneuronal activity, and the same peripheral variables associated with these acts in normal animals. The third aim is to repeat this study of the motor cortex in the presence of induced muscle pain. The applicant hypothesizes that cortical neurons provide signals correlated with the initiation and execution of jaw movements and the maintenance of jaw positions, and that the signals change during the conscious pain experience in such a way as alter muscle contraction patterns, and subsequent jaw motion. They consider that their preliminary data support this proposition. The alternative hypothesis proposed is that this change in cortical signalling does not occur, in which case the applicant will conclude that the pain-adaptation response is due primarily to brainstem mechanisms. The applicant believes the study is significant because it can provide a better understanding of cortical influences in the control of jaw movement generally, and in particular, define the cortex's role in human motor responses to jaw muscle pain.

描述（根据调查员的摘要进行了改编）： 建议是了解与颞下颌相关的肌肉疼痛如何 疾病（TMD）会影响灵长类动物的神经运动性能。 当前的 有证据表明，人类至少某些肌颌骨疼痛会引起 保护性适应反应，其中活性下降 激动剂肌肉和拮抗剂肌肉的活性增加，导致 下颌运动的受限范围。 目前，一个假设的脑干模型 已经提出要解释这一点，但同样有可能更高 还涉及电动机控制水平，例如电动机皮层 或而不是脑干。 虽然有意识地回应疼痛，并且 控制下颌肌肉收缩都涉及感觉运动皮层， 地区对保护性适应反应的潜在贡献 没有被研究。 由于申请人已经开发了合适​​的动物 在清醒猴子中产生瞬态下颌肌肉疼痛的模型（Macaca Mulatta）并观察其对自愿下巴运动和下巴的影响 位置，第一个目的是进行参数分析 刻板的运动任务期间正常的下颌运动和肌肉活动 自动咀嚼，并在诱导的情况下重复实验 肌肉疼痛。 第二个目的是定义类型之间的关系 皮质瘤性神经元活动的位置和相同的外围 与正常动物中的这些作用相关的变量。 第三个目标是 在诱发肌肉的情况下重复此运动皮层的研究 疼痛。 申请人假设皮质神经元提供信号 与下颌运动的启动和执行相关， 维护下颌位置，并且信号在 有意识的疼痛经历，例如改变肌肉收缩 图案和随后的下颌运动。 他们认为他们的初步 数据支持此主张。 提出的另一种假设是 不会发生这种皮质信号的变化，在这种情况下 申请人将得出结论，疼痛适应反应主要是由于 脑干机制。 申请人认为这项研究很重要 因为它可以更好地了解皮质影响 通常控制颌骨运动，尤其是定义皮质的 在人类运动对下颌肌肉疼痛的反应中的作用。