Development of a novel method for detailed evaluation of blood flow patterns in stented segments and assessment of their role in stent thrombosis

开发一种详细评估支架段血流模式及其在支架血栓形成中的作用的新方法

• 批准号: MR/X009068/1
• 负责人: Christos Bourantas
• 金额: $ 36.99万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FX009068%2F1
• 关键词: Development; novel; method; detailed; evaluation

Stents are used today to treat the blockages of the vessels of the heart in patients who have angina or suffered a heart attack. In most of these patients, stent treatment is effective and improves symptoms and life expectancy. However, there is a small proportion of patients where the stents fail and block, causing either death or a major heart attack. Studies in animals have shown that the blood flow patterns following stent implantation can predict stents that are at risk to block. However, there is lack of data about the role of blood flow on stent blockage in humans. This is because it is very difficult to create models of the vessels of the heart that have been treated with stents. This study aims to address this problem. We will analyse images of the vessels of the heart taken by a wire that is advanced in these vessels. In these images we can see details of the vessel wall and of the stent. We will use these images to create models of the vessels treated with stents using a new method that we have developed and then we will simulate blood flow in these models to assess the flow patterns. We will do that at scale in 120 patients of whom 40 had a heart attack because of a blocked stent. We will then compare the flow patterns in stents that blocked and caused a heart attack and in vessels treated with stents that did not cause an event. We believe that this research will allow us to identify the flow patterns that can cause stent blockage. This information is important as it will help us to improve the design of future stents and also the way that we put stents so as to reduce the risk of stent blockage and future heart attacks.

如今，支架用于治疗心绞痛或心脏病发作患者的心脏血管阻塞。对于大多数此类患者，支架治疗是有效的，可以改善症状并延长预期寿命。然而，有一小部分患者的支架失效并阻塞，导致死亡或严重心脏病发作。动物研究表明，支架植入后的血流模式可以预测支架有阻塞的风险。然而，缺乏关于血流对人体支架阻塞的作用的数据。这是因为创建经过支架治疗的心脏血管模型非常困难。本研究旨在解决这个问题。我们将分析由进入这些血管的导线拍摄的心脏血管图像。在这些图像中，我们可以看到血管壁和支架的细节。我们将使用这些图像，使用我们开发的新方法创建支架治疗的血管模型，然后我们将模拟这些模型中的血流以评估血流模式。我们将对 120 名患者进行大规模实验，其中 40 名患者因支架堵塞而心脏病发作。然后，我们将比较阻塞并导致心脏病发作的支架和使用未引起事件的支架治疗的血管中的血流模式。我们相信这项研究将使我们能够识别可能导致支架堵塞的流动模式。这些信息很重要，因为它将帮助我们改进未来支架的设计以及放置支架的方式，从而降低支架堵塞和未来心脏病发作的风险。