INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN

成人和儿童的传染性病原体和疫苗

基本信息

项目摘要

The purpose of this contract is to understand the pathogenesis of important respiratory and enteric viral pathogens of humans and to develop means to prevent illness caused by these viruses. Johns Hopkins University will provide volunteers and a facility in which to study the biology of medically important viruses in humans, to examine the hosts' immune response to these viruses and to test new candidate live virus vaccines for safety, genetic stability, immunogenicity, transmissibility and protective efficacy Studies will also include administration of wild type viruses to volunteers in order to assess virulence. Subsequently, these wild viruses will be used to challenge vaccinated volunteers in order to assess the extent of immunity induced by candidate vaccines. Studies with vaccines will include an evaluation of their safety, immunogenicity, transmissibility, and protective safety. These studies will include both adult and pediatric subjects since the viruses studied cause disease in both these populations; e.g., influenza A viruses causes severe respiratory disease in the elderly and, conversely, respiratory syncytial virus causes severe respiratory disease in infants. In summary, this contract will provide both the facility and volunteers, (adult and pediatric populations) to study the biology and immunology of a variety of viral pathogens and will serve as a testing center for the development of new vaccines effective against these agents.
该合同的目的是了解 人类的重要呼吸和肠病毒病原体并发展 预防这些病毒引起的疾病的手段。 约翰·霍普金斯 大学将为志愿者提供研究 人类医学上重要病毒的生物学,检查宿主的生物学 对这些病毒的免疫反应并测试新的候选活病毒 安全性,遗传稳定性,免疫原性,传播性的疫苗 保护功效研究还将包括野生 为志愿者键入病毒以评估毒力。随后, 这些野生病毒将用于挑战接种式志愿者 为了评估候选疫苗诱导的免疫力程度。 疫苗的研究将包括评估其安全性, 免疫原性,传播性和保护性安全性。 这些研究将包括成人和儿科受试者 病毒研究引起这两个人群的疾病。例如,流感 病毒在老年人中引起严重的呼吸道疾病, 相反,呼吸道合胞病毒会引起严重的呼吸系统疾病 在婴儿中。 总而言之,该合同将同时提供设施和 志愿者(成人和儿科人群)研究生物学和 多种病毒病原体的免疫学,将作为测试 针对这些药物有效的新疫苗开发中心。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据

数据更新时间:2024-06-01

MARY L CLEMENTS的其他基金

INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2298201
    2298201
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    6158950
    6158950
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2858261
    2858261
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2298204
    2298204
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2298200
    2298200
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    6365891
    6365891
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2662824
    2662824
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2722216
    2722216
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    6334494
    6334494
  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:
AIDS VACCINE EVALUATION UNIT
艾滋病疫苗评估单位
  • 批准号:
    2294586
    2294586
  • 财政年份:
    1990
  • 资助金额:
    $ 67.4万
    $ 67.4万
  • 项目类别:

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  • 批准号:
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INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    6158950
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  • 财政年份:
    1996
  • 资助金额:
    $ 67.4万
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INFECTIOUS AGENTS AND VACCINES IN ADULTS AND CHILDREN
成人和儿童的传染性病原体和疫苗
  • 批准号:
    2858261
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    $ 67.4万
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  • 项目类别: