Mathematics to underpin and drive novel inertial microfluidic technologies

数学支撑和驱动新型惯性微流体技术

• 批准号: DP240101089
• 负责人: Prof Yvonne Stokes
• 金额: $ 31.6万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101089
• 关键词: Mathematics; underpin; drive; novel; inertial

Particles suspended in flow through microfluidic ducts migrate under inertial and drag forcing to different regions in the cross-section depending on particle size, duct geometry and control parameters, enabling isolation of, for example, cancer cells/microplastics from a blood/water sample. Device design needs mathematical models yielding understanding of the particle dynamics, and tools for determining geometry and control parameters. Particle boundary conditions strongly influence the inertial lift and drag forces that drive particle motion. This project will develop these mathematical tools for boundary conditions applicable to both passive and active particles, so driving development of novel devices for existing and new applications.

悬浮在微流体管道流中的颗粒在惯性下迁移并拖动在横截面中的不同区域，具体取决于粒径，管道的几何和控制参数，从而可以从血液/水样品中分离出例如癌细胞/微塑料。设备设计需要数学模型，以了解粒子动力学的理解，以及用于确定几何和控制参数的工具。粒子边界条件强烈影响驱动颗粒运动的惯性提升和阻力。该项目将开发这些数学工具，以适用于适用于被动颗粒和活动粒子的边界条件，因此为现有和新应用程序开发了新的设备。