Mathematics to underpin and drive novel inertial microfluidic technologies

数学支撑和驱动新型惯性微流体技术

• 批准号: DP240101089
• 负责人: Prof Yvonne Stokes
• 金额: $ 31.6万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101089
• 关键词: Mathematics; underpin; drive; novel; inertial

Particles suspended in flow through microfluidic ducts migrate under inertial and drag forcing to different regions in the cross-section depending on particle size, duct geometry and control parameters, enabling isolation of, for example, cancer cells/microplastics from a blood/water sample. Device design needs mathematical models yielding understanding of the particle dynamics, and tools for determining geometry and control parameters. Particle boundary conditions strongly influence the inertial lift and drag forces that drive particle motion. This project will develop these mathematical tools for boundary conditions applicable to both passive and active particles, so driving development of novel devices for existing and new applications.

悬浮在微流体管道中的颗粒在惯性和阻力作用下迁移到横截面的不同区域，具体取决于颗粒尺寸、管道几何形状和控制参数，从而能够从血液/水样本中分离癌细胞/微塑料等。设备设计需要能够理解粒子动力学的数学模型，以及用于确定几何形状和控制参数的工具。粒子边界条件强烈影响驱动粒子运动的惯性升力和阻力。该项目将开发适用于被动和主动粒子边界条件的数学工具，从而推动现有和新应用的新型设备的开发。