Novel interventions for eliminating one- health mobile antimicrobial resistance genes from human and animal microbiomes

用于消除人类和动物微生物组中单一健康移动抗菌素耐药性基因的新干预措施

• 批准号: MR/W031361/1
• 负责人: Craig MacLean
• 金额: $ 47.94万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW031361%2F1
• 关键词: Novel; interventions; eliminating; health; mobile; Novel; interventions; eliminating; health; mobile

Antibiotic resistant bacteria pose a fundamental threat to human health. There is growing recognition that the genes that make bacteria resistant to antibiotics (AMR genes) are transferred between bacteria from agricultural animals and bacteria associated with humans. This exchange of AMR genes is mediated by self-replicating DNA molecules called plasmids that have the ability to transfer between bacterial cells. In this project we will test the ability of specialised viruses that target the plasmid transfer machinery to limit the spread of AMR genes in isolated pathogen populations and complex bacterial communities. Ultimately, this project will lead to the development of new phage based approaches for eradicating AMR genes from humans and agricultural animals that act as important sources of AMR genes, particularly in LMIC settings.

抗生素耐药细菌对人类健康构成了根本威胁。人们越来越认识到，使细菌对抗生素具有抗生素（AMR基因）的基因在农业动物的细菌和与人类相关的细菌之间转移。这种AMR基因的交换是通过称为质粒的自我复制DNA分子介导的，这些DNA分子具有在细菌细胞之间转移的能力。在这个项目中，我们将测试针对质粒转移机制的专用病毒的能力，以限制AMR基因在孤立的病原体种群和复杂细菌群落中的传播。最终，该项目将导致开发基于噬菌体的新方法，用于从人类和农业动物中消除AMR基因，这些方法是AMR基因的重要来源，特别是在LMIC环境中。