PARALLEL GENESIS: EXPERIENCE & OPTIMIZATION

平行创世：经验

• 批准号: 6122395
• 负责人: NIGEL H GODDARD
• 金额: --
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122395
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; computers; nervous system

This computational work addresses three orthopaedic research problems: simulating bone adaptation around an implant; calculating electric fields induced in bone by exogenous magnetic fields; and quantifying fluid flow in a mechanically loaded bone. Simulating bone adaptation is accomplished by applying physiological loads and constraints to a finite element model of the canine distal femur and using a bone remodeling finite element program to model the changes in porosity and architecture of the bone surrounding an implant experimentally inserted in the femur. The remodeling finite element code has successfully been used on the C90, and additional runs are needed to further explore the effects of different loading conditions on the resulting bone adaptation. The electric field problem is part of a project that is aimed at relating bone adaptation to electric field intensity to find a relationship between the applied fields and the biological response in a turkey model. Co des utilizing the finite element method and the finite difference method will be explored to find an optimal way to quantify the induced electric fields in a turkey wing that is exposed to a time-varying magnetic field. For the problem of fluid flow in bone, the interaction between the bone fluid and the bone matrix will be investigated using a finite element model also based upon a turkey model. First a finite element model of a bone mechanically loaded to mimic experimental loading conditions will be run to calculate displacements and strains on the bone-organ level. These displacements and strains will then be used as boundary conditions for a bone-tissue model that includes the small bone channels through which bone fluid flows. A finite element code that induces fluid-structure interaction will be investigated.

这项计算工作涉及三个骨科研究 问题：模拟植入物周围的骨骼适应；计算 外源磁场在骨骼中感应产生的电场；和 量化机械负载骨骼中的流体流量。 模拟骨骼 适应是通过施加生理负荷来完成的 对犬股骨远端有限元模型的约束 使用骨骼重塑有限元程序来模拟骨骼的变化 植入物周围骨骼的孔隙率和结构 实验性地插入股骨。 重构有限元 代码已成功在 C90 上使用，并且还需要进行额外的运行 需要进一步探索不同负载条件的影响 关于由此产生的骨适应。 电场问题是一部分 一个旨在将骨骼适应与电力联系起来的项目 场强度以找出所施加的场和 火鸡模型中的生物反应。 代码利用 有限元法和有限差分法 探索寻找量化感应电动势的最佳方法 暴露于时变磁场的火鸡翅膀中的磁场 场地。 对于骨骼中的流体流动问题， 骨液和骨基质将使用有限的 元素模型也基于火鸡模型。 首先是有限元 模拟实验负载的机械负载骨骼模型 将运行条件来计算位移和应变 骨器官水平。 然后将使用这些位移和应变 作为包括小骨组织模型的边界条件 骨液流动的骨通道。 有限元代码 将研究引起流体-结构相互作用的因素。