PARALLEL GENESIS: EXPERIENCE & OPTIMIZATION

平行创世：经验

• 批准号: 6122395
• 负责人: NIGEL H GODDARD
• 金额: --
• 依托单位: MELLON PITTS CORPORATION (MPC CORP)
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122395
• 关键词: bioengineering /biomedical engineering; biological products; biomedical resource; computers; nervous system

This computational work addresses three orthopaedic research problems: simulating bone adaptation around an implant; calculating electric fields induced in bone by exogenous magnetic fields; and quantifying fluid flow in a mechanically loaded bone. Simulating bone adaptation is accomplished by applying physiological loads and constraints to a finite element model of the canine distal femur and using a bone remodeling finite element program to model the changes in porosity and architecture of the bone surrounding an implant experimentally inserted in the femur. The remodeling finite element code has successfully been used on the C90, and additional runs are needed to further explore the effects of different loading conditions on the resulting bone adaptation. The electric field problem is part of a project that is aimed at relating bone adaptation to electric field intensity to find a relationship between the applied fields and the biological response in a turkey model. Co des utilizing the finite element method and the finite difference method will be explored to find an optimal way to quantify the induced electric fields in a turkey wing that is exposed to a time-varying magnetic field. For the problem of fluid flow in bone, the interaction between the bone fluid and the bone matrix will be investigated using a finite element model also based upon a turkey model. First a finite element model of a bone mechanically loaded to mimic experimental loading conditions will be run to calculate displacements and strains on the bone-organ level. These displacements and strains will then be used as boundary conditions for a bone-tissue model that includes the small bone channels through which bone fluid flows. A finite element code that induces fluid-structure interaction will be investigated.

这项计算工作解决了三项骨科研究 问题：模拟植入物周围的骨骼适应；计算 外源磁场在骨骼中诱导的电场；和 量化机械负载的骨骼中的流体流动。 模拟骨头 适应是通过施加生理负荷和 对犬远端股骨的有限元模型的约束和 使用骨骼重塑有限元程序来建模 植入物周围骨骼的孔隙和建筑 实验插入股骨。 重塑有限元 代码已在C90上成功使用，并且其他运行是 需要进一步探索不同加载条件的影响 在由此产生的骨适应上。 电场问题是一部分 旨在将骨骼适应与电气相关的项目 田间强度，以找到应用字段和 土耳其模型中的生物反应。 利用 有限元方法和有限差法为 探索以找到一种量化诱导电的最佳方法 暴露于时变磁的火鸡机翼的田地 场地。 对于骨骼流体流动的问题， 骨流体和骨基质将使用有限的 元素模型也基于土耳其模型。 首先是有限元 机械加载到模拟实验载荷的骨骼模型 条件将被运行以计算位移和应变 骨器器水平。 然后将使用这些位移和应变 作为骨组织模型的边界条件，包括小 骨通道通过，骨流体流动。 有限元代码 将研究诱导流体结构相互作用。