COMPUTATIONAL STUDY OF HORMONE BINDING DETERMINANTS IN HGHBP COMPLEX

HGHBP 复合物中激素结合决定因素的计算研究

• 批准号: 6220250
• 负责人: Shuanghong Huo
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220250
• 关键词: AIDS; biological products; biomedical resource; biotechnology; immunology; infection; inflammation; lymphatic system; statistics /biometry; virus

Alanine scanning is a well established experimental strategy to identify the specific side chain interaction between proteins. However, this strategy is labor and time consuming. We are developing a computational strategy to determine the specific side chain interaction between human growth hormone and receptor. This strategy requires only a single run of molecular dynamic simulations with free energy analysis following. We visualize the hormone-receptor complex, especially the binding site. The interactive computer graphics resources are very useful for examining our simulation results.

丙氨酸扫描是一种成熟的实验策略 识别蛋白质之间的特定侧链相互作用。 然而，这种策略既费力又费时。 我们正在开发 确定特定侧链的计算策略 人类生长激素和受体之间的相互作用。 这个策略 只需要运行一次分子动力学模拟即可免费 能量分析如下。 我们想象激素受体复合物， 特别是结合位点。 交互式计算机图形学 资源对于检查我们的模拟结果非常有用。