TestEd: Developing and evaluating an affordable whole-system approach for early detection of viral infections in workplaces and communities

TestEd：开发和评估一种经济实惠的全系统方法，用于早期检测工作场所和社区的病毒感染

• 批准号: MR/W006243/1
• 负责人: Timothy Aitman
• 金额: $ 231.64万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FW006243%2F1
• 关键词: TestEd; Developing; evaluating; affordable; whole

The TestEd programme at the University of Edinburgh will develop and evaluate an affordable whole system approach for early detection of COVID-19 that will provide a blueprint for large-scale regular testing to protect workplaces and communities from COVID-19 and, potentially, future pandemics. Specifically we will:- Implement our system that has now been established in two Institutes of the University of Edinburgh for streamlined, effective and accessible participant and sample registration, COVID-19 based on novel sample pooling strategies, automated, timely feedback of results, across the entire University of Edinburgh population, for twice weekly testing and rapid isolation of asymptomatic carriers- Conduct online surveys of all participants, and qualitative interviews on those who test positive for the virus, to understand attitudes and behaviour in the face of the pandemic, and the views of staff and students regarding regular testing and the potential need for self-isolation- Carry out health economic modelling of the pipeline, including our strategy to test for the virus in pooled samples that our preliminary analyses (see Additional Information Form) have shown have the potential for tests costing 40p per sample, at least ten-fold lower than other testing strategies- Evaluate efficacy and efficiency of the two pooling strategies - PCR-based hypercube pooling and sequence-based SwabSeq - by side-by-side comparison of their performance against individual PCR tests on a minimum of 10,000 samples and then, by using the pooling strategy with better performance, to test half a million samples collected from University staff and students within the 12 month period of the award- Engage with our collaborators within and outside the University to optimise the logistics of our laboratory processes, thereby minimising the time of each laboratory step and hands-on lab staff time, maximising use of robotic automation, thereby minimising overall turnaround time. Our current turnaround time is 100% return of results within 24 hours of the end of the 8-hour sample collection period. We shall monitor this through the course of the study period, providing reports to our participant community and to the MRC, aiming to remain as close as possible to 100% return of results within 24 hours throughout scale up and to full testing capacity- Engage with our participant community, the University leadership team, our collaborators within the NHS, our collaborators providing equipment and reagents and Edinburgh Innovations (our technology transfer organisation) to develop opportunities for future funding and deployment of our pipeline and knowhow within and outside the University at the conclusion of the funding period. This includes the opportunity to work with Government and non-governmental organisations to influence policy and to deploy our system, knowledge and experience to other workplaces and communities- Engage with policymakers and healthcare providers to ensure that our results and experience with large-scale testing can be fed into national and possibly international policy and practice for pandemic responses.

爱丁堡大学经过的测试计划将开发和评估一种可负担得起的整体系统方法，用于早期检测Covid-19，该方法将为大规模定期测试提供蓝图，以保护Covid-19的工作场所和社区，并有可能，并有潜在的未来大流行。 Specifically we will:- Implement our system that has now been established in two Institutes of the University of Edinburgh for streamlined, effective and accessible participant and sample registration, COVID-19 based on novel sample pooling strategies, automated, timely feedback of results, across the entire University of Edinburgh population, for twice weekly testing and rapid isolation of asymptomatic carriers- Conduct online surveys of all participants, and qualitative interviews on those谁对病毒测试呈阳性，了解大流行时的态度和行为，以及员工和学生对定期测试以及对自我溶解的潜在需求的看法 - 进行管道的健康经济模型，包括我们在汇总样本中测试病毒的策略，这些样本的汇总样本策略是我们的初步分析（请参阅其他信息表现出的策略），至少是针对每40点进行测试，而不是针对每40点进行策略，而不是针对每40点进行策略。两种汇总策略的功效和效率 - 基于PCR的超立即集合和基于序列的Swabseq-并排比较其性能与单个PCR测试至少在10,000个样本中与单独的PCR测试进行比较，然后通过以更好的绩效进行汇总策略，以更好的效果，以在我们的12个月内收集的一百万个月份的授予我们在我们的奖励中收集的一百万个月份的样本，以我们的奖励范围内，我们在我们的奖励中进行了优化，该过程是在我们的奖励中纳入我们的范围内的，该公司在我们的工作中均与我们的合作者互动，并在我们的范围内进行了合作，并在我们的工作人员中进行了合作。从而最大程度地减少了每个实验室步骤和动手实验室工作人员时间的时间，从而最大程度地使用机器人自动化，从而最大程度地减少了整体周转时间。我们目前的周转时间是在8小时样品收集期结束后24小时内的结果回报率100％。 We shall monitor this through the course of the study period, providing reports to our participant community and to the MRC, aiming to remain as close as possible to 100% return of results within 24 hours throughout scale up and to full testing capacity- Engage with our participant community, the University leadership team, our collaborators within the NHS, our collaborators providing equipment and reagents and Edinburgh Innovations (our technology transfer organisation) to develop opportunities for future funding and deployment of our pipeline and在资助期结束时，大学内部和外部都知道。这包括与政府和非政府组织合作的机会，以影响政策，并将我们的系统，知识和经验部署到其他工作场所和社区 - 与政策制定者和医疗保健提供者互动，以确保我们的大规模测试的结果和经验可以为民族和可能的国际政策和可能的国际政策和实践提供，以实现PANDMOCAGIC POMICAMIC PAMPOGIC。

项目成果

Knowledge, Attitudes, and Behavior Related to COVID-19 Testing: A Rapid Scoping Review.

• DOI: 10.3390/diagnostics11091685
• 发表时间: 2021-09-15
• 期刊: Diagnostics (Basel, Switzerland)
• 作者: Bevan I;Stage Baxter M;Stagg HR;Street A
• 通讯作者: Street A

Students' and staffs' views and experiences of asymptomatic testing on a university campus during the COVID-19 pandemic in Scotland: a mixed methods study.

• DOI: 10.1136/bmjopen-2022-065021
• 发表时间: 2023-03-20
• 期刊: BMJ open
• 影响因子: 2.9