DYNAMIC CARDIAC SPECT IMAGING

动态心脏光谱成像

• 批准号: 2638004
• 负责人: GRANT T GULLBERG
• 金额: $ 39.63万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2638004
• 关键词: adenosine; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder model; dogs; heart disorder diagnosis; heart function; heart imaging /visualization /scanning; heart motion; human tissue; intracardiac volume; myocardial ischemia /hypoxia; nuclear medicine; phantom model; radionuclides; radiopharmacology; reperfusion; single photon emission computed tomography; technetium; titanium

Single photon emission computed tomography (SPECT) has become an important tool in the diagnosis of heart disease, primarily because it has demonstrated an important clinical role in evaluating myocardial ischemia and more recently in evaluating myocardial viability. Over the last several years, (201)Tl has been the primary radiopharmaceutical used for cardiac SPECT. More recently, agents like sestamibi and teboroxime labelled with (99m)Tc have been developed to replace (201)Tl. The isotope(99m)Tc is more desirable than (201)Tl because of its better photon energy and radiation absorbed dose properties. However, these agents have not totally replaced (201)Tl due in part to their physiological characteristics. In particular, teboroxime has a fast wash-in and wash-out from the heart which requires rapid tomographic acquisitions which previously has not been feasible. However, with the advancement of multi- detector SPECT systems, we have demonstrated that dynamic cardiac SPECT imaging of teboroxime is possible. The development of dynamic cardiac SPECT has the potential to offer a more sensitive measure of ischemia than the present static SPECT techniques using (201)Tl. The goal of this proposal is to prescribe clinical protocols for dynamic SPECT imaging of the heart that are able to acquire complete projection sets every 5-10 seconds of a full three-dimensional tissue distribution of a short biological half-life radiopharmaceutical and to develop mathematical tools to extract from the dynamically acquired data a three- dimensional spatial distribution of kinetic parameters in the left ventricular myocardial tissue of blood volume fraction and wash-in (k21) and wash-out (k12) rate constants. The proposal will develop the applied mathematical tools to accurately and precisely quantify kinetic parameters and systematically evaluate these methods with computer simulations, canine experiments and clinical studies. At the completion of this proposal equipment requirements will also be specified. This proposal draws upon the physiological modeling development in PET. At present, PET is much further advanced than SPECT in utilizing dynamic imaging to extract kinetic parameters of organ systems. It is the intent of this proposal to develop methods that would be able to use existing multi-detector SPECT systems; and, in so doing, to provide improved health care to the general public through better detectability of myocardial infarcts, better diagnosis of ischemic heart disease, and better evaluation of tissue viability without adding additional cost to the SPECT procedure. Many of the methods developed will also be applicable to other organ systems such as the kidney and the brain.

单光子发射计算机断层扫描（SPECT）已成为重要 心脏病诊断的工具，主要是因为它具有 在评估心肌缺血中表现出重要的临床作用 最近在评估心肌生存力方面。最后 几年，（201）TL是用于用于的主要放射性药物 心脏幽灵。最近，像Sestamibi和Teboroxime这样的代理商 已经开发了带有（99m）TC的标签以取代（201）TL。这 同位素（99m）TC比（201）TL更可取，因为它的光子更好 能量和辐射吸收的剂量特性。但是，这些代理商有 并非完全取代（201）TL，部分原因是他们的生理 特征。特别是，Teboroxime具有快速洗涤和洗涤 需要快速的层析成像习得的心脏 以前不可行。但是，随着多数的发展 检测器SPECT系统，我们已经证明了动态心脏SPECT 有可能的teboroxime成像。动态心脏的发展 SPECT具有比相比提供更敏感的缺血度量的 当前使用（201）TL的静态SPECT技术。 该提案的目的是规定动态的临床方案 能够获得完整投影的心脏成像 每5-10秒的完整三维组织分布 一个简短的生物半衰期放射性药物并发展 从动态获取的数据中提取的数学工具三 左侧动力学参数的维空间分布 血液体积分数和洗涤的心室心肌组织（K21） 和冲洗（K12）速率常数。该提案将开发应用 数学工具准确，精确地量化动力学参数 并通过计算机模拟系统地评估这些方法， 犬实验和临床研究。完成此过程 建议设备要求也将指定。 该建议借鉴了宠物的生理建模发展。在 目前，宠物比SPECT在利用动态方面要进展得多 成像提取器官系统的动力学参数。这是意图 该提议开发的方法可以使用现有的方法 多探测器SPECT系统；而且，这样做以提供改善的健康 通过更好的心肌检测性来照顾公众 梗塞，更好地诊断缺血性心脏病，更好 评估组织生存能力而不增加SPECT的额外成本 程序。开发的许多方法也将适用于其他 器官系统，例如肾脏和大脑。