DYNAMIC CARDIAC SPECT IMAGING

动态心脏光谱成像

• 批准号: 2638004
• 负责人: GRANT T GULLBERG
• 金额: $ 39.63万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2638004
• 关键词: adenosine; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder model; dogs; heart disorder diagnosis; heart function; heart imaging /visualization /scanning; heart motion; human tissue; intracardiac volume; myocardial ischemia /hypoxia; nuclear medicine; phantom model; radionuclides; radiopharmacology; reperfusion; single photon emission computed tomography; technetium; titanium

Single photon emission computed tomography (SPECT) has become an important tool in the diagnosis of heart disease, primarily because it has demonstrated an important clinical role in evaluating myocardial ischemia and more recently in evaluating myocardial viability. Over the last several years, (201)Tl has been the primary radiopharmaceutical used for cardiac SPECT. More recently, agents like sestamibi and teboroxime labelled with (99m)Tc have been developed to replace (201)Tl. The isotope(99m)Tc is more desirable than (201)Tl because of its better photon energy and radiation absorbed dose properties. However, these agents have not totally replaced (201)Tl due in part to their physiological characteristics. In particular, teboroxime has a fast wash-in and wash-out from the heart which requires rapid tomographic acquisitions which previously has not been feasible. However, with the advancement of multi- detector SPECT systems, we have demonstrated that dynamic cardiac SPECT imaging of teboroxime is possible. The development of dynamic cardiac SPECT has the potential to offer a more sensitive measure of ischemia than the present static SPECT techniques using (201)Tl. The goal of this proposal is to prescribe clinical protocols for dynamic SPECT imaging of the heart that are able to acquire complete projection sets every 5-10 seconds of a full three-dimensional tissue distribution of a short biological half-life radiopharmaceutical and to develop mathematical tools to extract from the dynamically acquired data a three- dimensional spatial distribution of kinetic parameters in the left ventricular myocardial tissue of blood volume fraction and wash-in (k21) and wash-out (k12) rate constants. The proposal will develop the applied mathematical tools to accurately and precisely quantify kinetic parameters and systematically evaluate these methods with computer simulations, canine experiments and clinical studies. At the completion of this proposal equipment requirements will also be specified. This proposal draws upon the physiological modeling development in PET. At present, PET is much further advanced than SPECT in utilizing dynamic imaging to extract kinetic parameters of organ systems. It is the intent of this proposal to develop methods that would be able to use existing multi-detector SPECT systems; and, in so doing, to provide improved health care to the general public through better detectability of myocardial infarcts, better diagnosis of ischemic heart disease, and better evaluation of tissue viability without adding additional cost to the SPECT procedure. Many of the methods developed will also be applicable to other organ systems such as the kidney and the brain.

单光子发射计算机断层扫描（SPECT）已成为重要的 诊断心脏病的工具，主要是因为它具有 在评估心肌缺血方面表现出重要的临床作用 最近还用于评估心肌活力。过去的 多年来，(201)Tl 一直是用于治疗的主要放射性药物。 心脏 SPECT。最近，塞他米比（sestamibi）和替硼辛（teboroxime）等药物 已开发出用 (99m)Tc 标记来替代 (201)Tl。这 同位素 (99m)Tc 比 (201)Tl 更理想，因为它具有更好的光子 能量和辐射吸收剂量特性。然而，这些代理有 未完全取代 (201)Tl，部分原因是其生理原因 特征。特别是，替硼肟具有快速的冲洗和冲洗效果 来自心脏，需要快速断层扫描采集 以前是不可行的。然而，随着多学科的进步 探测器 SPECT 系统，我们已经证明动态心脏 SPECT 替硼肟成像是可能的。动态心脏发育 SPECT 有可能提供比 目前的静态 SPECT 技术使用 (201)Tl。 该提案的目标是制定动态临床方案 能够获得完整投影的心脏 SPECT 成像 每 5-10 秒设置一次完整的三维组织分布 短生物半衰期放射性药物并开发 数学工具从动态获取的数据中提取三 左侧动力学参数的维度空间分布 心室心肌组织的血容量分数和洗入（k21） 和洗脱 (k12) 速率常数。该提案将开发应用 精确量化动力学参数的数学工具 并通过计算机模拟系统地评估这些方法， 犬实验和临床研究。完成本次操作后 提案的设备要求也将被指定。 该提案借鉴了 PET 生理模型的发展。在 目前，PET 在利用动态检测方面比 SPECT 先进得多。 成像以提取器官系统的动力学参数。这就是意图 该提案的目的是开发能够利用现有技术的方法 多探测器 SPECT 系统；并以此改善健康状况 通过更好地检测心肌来为公众提供护理 梗塞、更好地诊断缺血性心脏病、以及 评估组织活力，无需增加 SPECT 的额外成本 程序。开发的许多方法也适用于其他 器官系统，例如肾脏和大脑。