Enabling technologies

支持技术

• 批准号: MC_UU_00014/5
• 负责人: Giles Yeo
• 金额: $ 427.56万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00014%2F5
• 关键词: Enabling; technologies; Enabling; technologies

The Enabling Technologies programme consists of a number of core facilities that provide critical technologies and equipment to scientists in the MDU and it is crucial its success. Because metabolic disease affects the entire body, it is vital to study these diseases whole animals. Our model of choice is the mouse. The Disease Model Core provides facilities for the measurement of the amount of fat and muscle in an animal’s body, how much and what type of food is eaten, and how much energy is burnt, through either metabolism, heat production, or exercise. It also provides facilities for examining isolated cells, tissues and organs. At the other end of the size spectrum, the Genomics/Transcriptomics Core enables scientists to study the sub-microscopic world of genes and how they function and are turned into proteins and the Core Biochemistry Assay Lab measures hormones and other molecules in blood.

支持技术计划由许多核心设施组成，这些设施为MDU的科学家提供关键的技术和设备，这至关重要。由于代谢疾病会影响整个身体，因此研究这些疾病至关重要。我们选择的模型是鼠标。疾病模型核心为测量动物体内脂肪和肌肉的数量，食用哪种类型的食物以及通过代谢，热量产生或运动燃烧多少能量提供了设施。它还提供了检查孤立细胞，组织和器官的设施。在大小光谱的另一端，基因组学/转录组学核心使科学家能够研究基因的亚显微镜世界及其功能，并如何变成蛋白质以及核心生物化学测定实验室测量血液中的激素和其他分子。