Malaria parasite population structure and adaptation on the edge of endemic distribution in Africa

非洲流行分布边缘的疟疾寄生虫种群结构和适应

• 批准号: G1100123/1
• 负责人: David Conway
• 金额: $ 63.34万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100123%2F1
• 关键词: Malaria; parasite; population; structure; adaptation

We aim to know how to better control malaria in one of the most disadvantaged populations of the world. There is very little medical research conducted in Mauritania, in the north western part of sub-Saharan Africa, but the information we have indicates that malaria is a problem throughout the south of the country where most of the population live - most of the north of the country is Saharan desert. However, the disease could probably be effectively controlled and possibly even eliminated in the long-term with appropriate efforts. In countries immediately to the south, particularly in The Gambia and Senegal, recent scale up of interventions has coincided with a significant decline in malaria. Although control in Mauritania may have lagged behind it is in a situation with only a short season of mosquito transmission where the parasites might be eliminated given the right approach. The investigating team at the London School of Hygiene and Tropical Medicine and the National Institute of Public Health Research in Mauritania are planning to use state of the art genomics and cell culture methods along with collaborators at Harvard University and the Wellcome Trust Sanger Institute in the UK as well as in neighbouring Senegal, to understand the parasite populations and how they adapt to antimalarial drugs and invade red cells in a population where most people have little immunity to the infection. This understanding may help target interventions to particular parts of Mauritania and also help in the design of a vaccine that could induce immunity against the stage of the parasite that invades red cells.

我们的目标是知道如何更好地控制世界上最弱势群体的疟疾。毛里塔尼亚的医学研究很少，在撒哈拉以南非洲的西北部进行，但我们表明的信息表明，疟疾是整个国家南部的一个问题，大多数人口都居住 - 该国北部大部分地区是撒哈拉沙漠。但是，这种疾病可能可以有效地控制，甚至可能在长期内通过适当的努力消除。在南部，特别是在冈比亚和塞内加尔的国家，最近的干预措施与疟疾的显着下降相吻合。尽管毛里塔尼亚的控制可能落后于它的情况，这只是蚊子传播的短季节，鉴于正确的方法，可以消除寄生虫。 The investigating team at the London School of Hygiene and Tropical Medicine and the National Institute of Public Health Research in Mauritania are planning to use state of the art genomics and cell culture methods along with collaborators at Harvard University and the Wellcome Trust Sanger Institute in the UK as well as in neighbouring Senegal, to understand the parasite populations and how they adapt to antimalarial drugs and invade red cells in a population where most people have little对感染的免疫力。这种理解可能有助于靶向毛里塔尼亚特定部位的干预措施，并有助于设计疫苗，该疫苗可以诱导免疫力，以抵抗入侵红细胞的寄生虫阶段。