Improving the Diagnosis and Treatment of Localised Prostate Cancer

改善局限性前列腺癌的诊断和治疗

• 批准号: G1002509/1
• 负责人: Hashim Ahmed
• 金额: $ 156.31万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002509%2F1
• 关键词: Improving; Diagnosis; Treatment; Localised; Prostate

The way we diagnose prostate cancer at the moment is flawed. At present, a blood test called the prostate specific antigen, or PSA, is used to decide who gets a prostate biopsy. Prostate biopsy is painful, causes bleeding and sometimes serious infections. It often detects harmless cancers that need no treatment and misses important cancers that do. This is because prostate biopsies are random - we cannot see the cancer so needles are fired into the prostate in the hope that we will hit the cancer. Once diagnosed, the way we treat early prostate cancer can cause a lot of harm. Current treatments for early prostate cancer target the whole prostate, causing damage to surrounding structures. This can lead to urine leak, poor erections and back passage problems.The researchI will test the ability of several markers in blood and urine as well as imaging to accurately predict the presence or absence of important prostate cancer. I will also test whether treating the cancer only, in order to avoid damaging surrounding structures, is effective in cancer control and whether the harms of whole-gland treatments can be reduced.The possible benefitsReduce the number of men who undergo unnecessary prostate biopsyReduce the risk of being diagnosed with a harmless prostate cancerImprove the diagnosis of prostate cancer that is importantReduce the harms of treatment

目前，我们诊断前列腺癌的方式存在缺陷。目前，使用称为前列腺特异性抗原或PSA的血液测试来决定谁进行前列腺活检。前列腺活检很痛苦，会导致出血，有时会导致严重的感染。它经常检测到无需治疗的无害癌症，并错过了重要的癌症。这是因为前列腺活检是随机的 - 我们看不到癌症，因此将针头发射到前列腺中，希望我们能击中癌症。一旦诊断出，我们治疗早期前列腺癌的方式可能会造成很大的伤害。当前对早期前列腺癌的治疗旨在整个前列腺，从而损害周围的结构。这可能导致尿液泄漏，勃起不良和后退问题。该研究将测试几种标记在血液和尿液中的能力，以及成像以准确预测重要的前列腺癌的存在或不存在。我还将测试是否仅治疗癌症，以避免损害周围的结构，对癌症控制有效，以及是否可以减少全gland治疗的危害。