From single units to local field potentials: Study of the timing of medial temporal lobe responses in humans

从单个单位到局部场电位：人类内侧颞叶反应时间的研究

• 批准号: G1002100/1
• 负责人: Hernan Rey
• 金额: $ 39.19万
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002100%2F1
• 关键词: single; units; local; field; potentials; single; units; local; field; potentials

It has been shown that neurons in the human ‘hippocampus‘, an area at the end of the pathway for processing sensory information, respond significantly later than in monkeys. A possible explanation is that this is due to the fact that humans process sensory stimuli much further to create abstract concepts and associations. But how does the brain keep the timing of these responses? How do these neurons know when to fire?To address this question, I will use recordings with intracranial electrodes placed in the brain of epileptic patients for clinical reasons. I will thoroughly study the temporal dynamics of the neural responses both in terms of the firing of individual neurons and the average activity of a large number of neurons, leading to the so called Local Field Potentials (LFPs). Particularly, I will explore whether the LFPs provide the timing information in the areas under study. Using different experimental manipulations, I will explore the consequences in the neural responses of variations of the timing for recognition and given that these areas are critical for memory storage, these finding may have long term relevance for improving our understanding on memory formation and memory disorders, such as Alzheimer‘s disease.

已经表明，人类“海马”中的神经元是处理感官信息的途径末端的一个区域，比猴子晚了。一个可能的解释是，这是由于人类对感官刺激进行了进一步的过程来创建抽象的概念和关联。但是，这些神经元如何知道何时开火？为了解决这个问题，我将出于临床原因使用带有颅内电极的记录。我将通过发射单个神经元和大量神经元的平均活性来彻底研究神经元的临时动力学，从而导致所谓的局部场电位（LFP）。特别是，我将探讨LFP是否在研究领域提供的时机信息。使用不同的实验操作，我将探讨识别时间变化的中性响应的后果，鉴于这些区域对于记忆存储至关重要，这些发现可能具有长期的相关性，可以提高我们对记忆形成和记忆障碍（例如阿尔茨海默氏病）的理解。