Bioactive orthopaedic implants using nanopatterned 3D materials

使用纳米图案 3D 材料的生物活性骨科植入物

• 批准号: G1000842/1
• 负责人: Nikolaj Gadegaard
• 金额: $ 91.66万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000842%2F1
• 关键词: Bioactive; orthopaedic; implants; using; nanopatterned

Today we live longer and longer, and at the same time we have a more active life than ever before. This means that younger and younger patients are now facing partial or total hip replacement. This combined with a longer life expectancy increases the possibility of revision surgery as the life span of prostheses is shorter than the patients? life expectancy. This possesses several problems. Firstly, the success of a hip replacement is lower for younger patients and as a result such surgical procedures are often being delayed by the surgeons. Secondly, revision surgery is significantly less successful and the lifetime of the prostheses is greatly reduced. A major step forward to increase the lifetime of a prosthesis has been for cementless implants. Here the surface of the implant has been roughened thus providing a better locking with the ingrowing bone. Nonetheless, there is still space for significant improvements of current implants. The bone marrow is a rich source of stem cells which can, provided the correct stimuli, become bone forming cells. When a hip implant in fitted during the surgical procedure it will come in direct contact with the bone marrow. We have discovered a specific nanopattern which promotes the stem cells from the bone marrow to become bone forming cells. This project will take our remarkable discovery from a Petri dish and turn the results into a new generation of orthopaedic implants with improved properties over current ones. To realise this ambitious goal we have devised a clear technology development plan combined with the necessary biological experiments to bring our technology to a large animal stage. Our initial results have been performed on patterned plastic surfaces. However, plastics do not have the required mechanical properties (strength) to be used for prostheses. Such load bearing implants are commonly made in titanium and we will develop methods to pattern such metal implants.To the best of our knowledge this will be a world s first to develop osseoinductive process (development of immature cells to bone forming cells) on an orthopaedic metal implant surface.

今天，我们寿命越来越长，与此同时，我们的生活比以往任何时候都更加活跃。这意味着年轻的患者现在面临部分或全髋关节置换。随着假体的寿命比患者短？预期寿命。这有几个问题。首先，年轻患者的髋关节置换成功率较低，因此，外科医生通常会延迟此类手术程序。其次，修订手术的成功明显较小，并且假体的寿命大大降低。提高假体寿命的主要一步是无水泥植入物。在这里，植入物的表面已经变得粗糙，从而为骨内的骨骼提供了更好的锁定。尽管如此，仍然有空间可以显着改善当前植入物。骨髓是干细胞的丰富来源，可以提供正确的刺激，成为骨形成细胞。当手术过程中安装的髋关节植入物将与骨髓直接接触。我们发现了一种特定的纳米图案，该纳米图案促进了从骨髓中促进干细胞成为骨形成细胞。该项目将从培养皿中获得我们的非凡发现，并将结果转变为新一代的骨科植入物，其特性比当前的植入物改进。为了实现这一雄心勃勃的目标，我们设计了一个清晰的技术开发计划，并结合了必要的生物学实验，以使我们的技术进入大型动物阶段。我们的最初结果是在图案塑料表面上进行的。但是，塑料没有用于假体的所需的机械性能（强度）。这种负载轴承植入物通常是在钛中制造的，我们将开发方法来对这种金属植入物进行模型。在我们的最佳知识中，这将是一个在骨科上开发osseo诱导过程（将未成熟细胞开发到骨形成细胞的世界）的世界。金属植入物表面。