Development of a magnetic guidance strategy for improving the trafficking of cellular therapies into tumours

开发磁性引导策略以改善细胞疗法进入肿瘤的运输

• 批准号: G0902317/1
• 负责人: Munitta Muthana
• 金额: $ 12.72万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902317%2F1
• 关键词: Development; magnetic; guidance; strategy; improving

Many current cancer treatments are limited by the failure to penetrate deep into the tumour. Monocytes and macrophages are specialist white blood cells which have been shown to enter tumours in large numbers often settling in these areas that are difficult to treat. Scientists have shown that these cells have the ability to kill tumour cells in the laboratory when they are stimulated with anticancer agents. This led doctors to remove these cells from cancer patients, stimulate them in the laboratory and reintroduce them back into the patients in an attempt to reduce cancer growth. While this method proved to be very safe, the signs of success were very small, mainly due to few monocytes/macrophages reaching the cancer. Now, a new magnetic targeting method has been developed in our laboratory to overcome this problem. This involves inserting tiny magnets into monocytes and injecting the ?magnetic cells? into the bloodstream. We have found if a small powerful magnet is then placed over the tumour to create a magnetic field this attracted many more monocytes into the tumour. The monocytes were found deep in the tumour in the areas which are difficult to access using current therapies like radiotherapy or chemotherapy. One of the advantages of this approach is that the magnet ensures delivery to only the tumour thus preventing damage to healthy organs. In our previous studies we used superficial tumours (under the skin) these were easy to locate and a small magnet was then placed on the surface of the skin. We now want to use magnetic resonance imaging (MRI), a technique widely applied in the clinic, to help guide our magnetic cells into cancers that are found deep in the body like metastasis. We then want to use this to deliver a number of anticancer agents that prevent tumour growth and metastasis as well as agents that directly kill the tumour. A discipline hopping grant will bring together two different areas of science, oncology and magnetic resonance physics, the combination of which is hoped to provide a valuable method where magnetic cells are forced into tumours in significantly greater numbers to attack the cancer. This new magnetic targeting approach could herald a new era in cancer treatment - one in which delivery of anti-cancer therapy to the diseased site is a great deal more effective.

许多当前的癌症治疗因素受到未能深入肿瘤的限制。单核细胞和巨噬细胞是专业的白细胞，已显示出大量进入肿瘤，这些肿瘤经常在这些地区难以治疗的区域定居。科学家表明，这些细胞在用抗癌剂刺激时可以杀死实验室中的肿瘤细胞。这导致医生从癌症患者中去除这些细胞，在实验室中刺激它们，并将其重新引入患者，以减少癌症的生长。尽管这种方法被证明是非常安全的，但成功的迹象很小，主要是由于几乎没有单核细胞/巨噬细胞到达癌症。现在，我们的实验室已经开发了一种新的磁靶方法，以克服这一问题。这涉及将微小磁铁插入单核细胞并注入？磁细胞？进入血液。我们发现，如果然后将一个小的强大磁铁放在肿瘤上以创建磁场，这吸引了更多的单核细胞进入肿瘤。在肿瘤中发现了单核细胞，而使用当前的放射疗法或化学疗法，难以进入的区域。这种方法的优点之一是磁铁可确保仅递送到肿瘤，从而防止对健康器官的损害。在以前的研究中，我们使用了浅表肿瘤（在皮肤下），这些肿瘤易于定位，然后将一个小磁铁放在皮肤表面上。现在，我们想使用磁共振成像（MRI）（MRI），这是一种在诊所广泛应用的技术，以帮助引导我们的磁细胞进入像转移一样在体内深处的癌症中。然后，我们想使用它来提供许多防止肿瘤生长和转移的抗癌药以及直接杀死肿瘤的药物。一项纪律赠款将汇集两个不同的科学领域，肿瘤学和磁共振物理学，其组合希望提供一种有价值的方法，其中磁细胞被迫将肿瘤迫使更多数量的肿瘤攻击以攻击癌症。这种新的磁性靶向方法可以预示癌症治疗的新时代 - 在这种治疗中，将抗癌治疗递送到患病部位的时代更为有效。