Induction and repair of UVAI (340-400nm) induced cyclobutane dimers (CPD) in human skin in vivo and their biological con

UVAI（340-400nm）诱导的人皮肤环丁烷二聚体（CPD）在体内的诱导和修复及其生物学意义

• 批准号: G0902027/1
• 负责人: Angela Tewari
• 金额: $ 32.75万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902027%2F1
• 关键词: Induction; repair; UVAI; 340; 400nm; Induction; repair; UVAI; 340; 400nm

Sunlight contains ultraviolet (UV) rays and these have been proven to cause skin cancer. There are two types of UV rays; UVA and UVB. Previous research has focussed on UVB which has been thought to be the main cause of skin cancer. However, recent test-tube research suggests that UVA may also cause skin cancer. This is important not only because sunlight contains at least 20 times more UVA than UVB, and sunbeds give out large amounts of UVA, but because doctors use high doses of UVA in hospitals to treat some skin diseases. This study will find out whether the harmful effects of UVA seen in the test-tube really occur in humans by researching with healthy volunteers and patients being treated with UVA therapy. The study matters because, if UVA is harmful to skin, health advice to the public about sun protection will have to change to include UVA, and doctors may have to limit the amount of UVA treatment they can safely give to patients. The work will be done by specialists on the effects of UV rays on skin at St John‘s Institute of Dermatology, London.

阳光含有紫外线（UV）射线，已被证明会引起皮肤癌。有两种类型的紫外线； UVA和UVB。先前的研究集中在UVB上，UVB被认为是皮肤癌的主要原因。但是，最近的试管研究表明，UVA也可能导致皮肤癌。这很重要，这不仅是因为阳光的含量至少是UVB的20倍，而且日光浴床会散发出大量UVA，而且由于医生在医院中使用高剂量的UVA来治疗某些皮肤疾病。这项研究将通过与健康的志愿者和接受UVA疗法治疗的健康志愿者进行研究，发现在人类中，UVA锯的有害作用是否确实发生在人类中。这项研究很重要，因为如果UVA对皮肤有害，那么对公众的健康建议就必须改变以包括UVA，并且医生可能必须限制他们可以安全地给予患者的UVA治疗量。这项工作将由专家就伦敦St John的皮肤病学研究所的紫外线对皮肤的影响进行。